(Q39009616)

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An activation of LC3A-mediated autophagy contributes to de novo and acquired resistance to EGFR tyrosine kinase inhibitors in lung adenocarcinoma

scientific article published on 18 August 2014

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Europe PubMed Central

PubMed publication ID

8 September 2017

An activation of LC3A-mediated autophagy contributes to de novo and acquired resistance to EGFR tyrosine kinase inhibitors in lung adenocarcinoma (English)

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Europe PubMed Central

PubMed publication ID

8 September 2017

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Hironobu Sasano

15

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Hironobu Sasano

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8 September 2017

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Yasuhiro Miki

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8 September 2017

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Kazushige Mori

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8 September 2017

Hisafumi Yamada-Okabe

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Hisafumi Yamada-Okabe

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Erina Iwabuchi

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Sodai Narumi

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Masahito Ebina

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8 September 2017

Mikiyoshi Saito

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Mikiyoshi Saito

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8 September 2017

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Ikuro Sato

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Makoto Maemondo

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Makoto Maemondo

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8 September 2017

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Kaito Nihira

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Kazue Ise

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author name string

Shinya Iida

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Katsuhiko Ono

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Takashi Kondo

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8 September 2017

publication date

18 August 2014

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8 September 2017

Journal of Pathology

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8 September 2017

234

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2

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8 September 2017

277-288

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8 September 2017

Treatment of non-small-cell lung cancer with erlotinib or gefitinib

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

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https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

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https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

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https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Factors underlying sensitivity of cancers to small-molecule kinase inhibitors

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https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Personalized medicine and inhibition of EGFR signaling in lung cancer

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https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

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https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

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https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

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https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Apoptosis and cancer: the genesis of a research field

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Lysosomes and autophagy in cell death control

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Autophagy: from phenomenology to molecular understanding in less than a decade

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Autophagy fights disease through cellular self-digestion

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

To die or not to die: that is the autophagic question

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

A transcriptional variant of the LC3A gene is involved in autophagy and frequently inactivated in human cancers

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Selective autophagy in cancer development and therapy

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Autophagy-deficient mice develop multiple liver tumors

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Autophagy as a second level protective process in conferring resistance to environmentally-induced oxidative stress

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Erlotinib-induced autophagy in epidermal growth factor receptor mutated non-small cell lung cancer.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Combination erlotinib-cisplatin and Atg3-mediated autophagy in erlotinib resistant lung cancer

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Studies on the mechanisms of autophagy: maturation of the autophagic vacuole

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

A guided tour into subcellular colocalization analysis in light microscopy

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Androgen and androgen-metabolizing enzymes in metastasized lymph nodes of breast cancer

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

A gene-alteration profile of human lung cancer cell lines.

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Lack of AKT activation in lung cancer cells with EGFR mutation is a novel marker of cetuximab sensitivity

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

A phase I study of erlotinib and hydroxychloroquine in advanced non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Enhanced autophagy is required for survival in EGFR-independent EGFR-mutant lung adenocarcinoma cells

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Autophagy-related proteins Beclin-1 and LC3 predict cetuximab efficacy in advanced colorectal cancer

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Autophagy-related proteins LC3 and Beclin-1 impact the efficacy of chemoradiation on esophageal squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Gene silencing in cancer in association with promoter hypermethylation

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

1 reference

https://api.crossref.org/works/10.1002%2FPATH.4354

21 January 2018

Identifiers

10.1002/PATH.4354

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

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