(Q39022950)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28083796%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

title

Approaches to Mitigate the Unwanted Immunogenicity of Therapeutic Proteins during Drug Development (English)

1 reference

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9 April 2020

3

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9 April 2020

author name string

Laura I Salazar-Fontana

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28083796%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Dharmesh D Desai

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28083796%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Renuka C Pillutla

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28083796%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Sandra Prior

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28083796%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Radha Ramakrishnan

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28083796%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Jennifer Schneider

7

1 reference

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9 April 2020

Alexandra Joseph

8

1 reference

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9 April 2020

language of work or name

English

0 references

publication date

12 January 2017

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9 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28083796%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

volume

19

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28083796%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

issue

2

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9 April 2020

page(s)

377-385

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Immunoregulatory functions of mTOR inhibition.

9 April 2020

cites work

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Oral delivery of Acid Alpha Glucosidase epitopes expressed in plant chloroplasts suppresses antibody formation in treatment of Pompe mice

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The effect of chronic daily cyclophosphamide administration on established antibody responses

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Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?

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Rapamycin passes the torch: a new generation of mTOR inhibitors

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Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance

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Effect of belimumab on vaccine antigen antibodies to influenza, pneumococcal, and tetanus vaccines in patients with systemic lupus erythematosus in the BLISS-76 trial.

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Immature Dendritic Cells Suppress Collagen-Induced Arthritis by In Vivo Expansion of CD49b+ Regulatory T Cells

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12 December 2020

Impact of product-related factors on immunogenicity of biotherapeutics

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12 December 2020

Coupling of aggregation and immunogenicity in biotherapeutics: T- and B-cell immune epitopes may contain aggregation-prone regions

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O-phospho-l-serine mediates hyporesponsiveness toward FVIII in hemophilia A-murine model by inducing tolerogenic properties in dendritic cells

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12 December 2020

FVIII inhibitor IgG subclass and FVIII polypeptide specificity determined by immunoblotting

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12 December 2020

Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products

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12 December 2020

Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose

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12 December 2020

Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals

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The gut microbiota shapes intestinal immune responses during health and disease

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12 December 2020

Taking immunogenicity assessment of therapeutic proteins to the next level.

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12 December 2020

Immunogenicity of engineered antibodies

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12 December 2020

Reducing the immunogenicity of protein therapeutics

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12 December 2020

Bortezomib in the rapid reduction of high sustained antibody titers in disorders treated with therapeutic protein: lessons learned from Pompe disease

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12 December 2020

Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule

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12 December 2020

Central tolerance: learning self-control in the thymus

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12 December 2020

Persistence of high sustained antibodies to enzyme replacement therapy despite extensive immunomodulatory therapy in an infant with Pompe disease: need for agents to target antibody-secreting plasma cells

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12 December 2020

Therapeutic challenges in acquired factor VIII deficiency

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12 December 2020

The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability

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12 December 2020

Immunopharmacology of rapamycin

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12 December 2020

Physical characterization and in vitro biological impact of highly aggregated antibodies separated into size-enriched populations by fluorescence-activated cell sorting

1 reference

12 December 2020

A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response

1 reference

12 December 2020

Induction of tolerogenic dendritic cells by NF-κB blockade and Fcγ receptor modulation

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12 December 2020

Aggregation of human recombinant monoclonal antibodies influences the capacity of dendritic cells to stimulate adaptive T-cell responses in vitro

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12 December 2020

De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR.

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12 December 2020

Immune tolerance induction to enzyme-replacement therapy by co-administration of short-term, low-dose methotrexate in a murine Pompe disease model

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12 December 2020

Factor VIII inhibitors in hemophilia A: rationale and latest evidence

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12 December 2020

Regulatory B cells mediate tolerance to apoptotic self in health: implications for disease

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12 December 2020

Boosting regulatory T cell function by CD4 stimulation enters the clinic

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12 December 2020

Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice

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12 December 2020

Relationship between potential aggregation-prone regions and HLA-DR-binding T-cell immune epitopes: implications for rational design of novel and follow-on therapeutic antibodies

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12 December 2020

Quantitative analysis of the CD4 T-cell repertoire specific to therapeutic antibodies in healthy donors

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12 December 2020

B-cell tolerance checkpoints in health and autoimmunity

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12 December 2020

Transgenic mice and analysis of B-cell tolerance

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12 December 2020

Transient low-dose methotrexate generates B regulatory cells that mediate antigen-specific tolerance to alglucosidase alfa

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12 December 2020

Human dendritic cell subsets

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12 December 2020

Cytokine-conditioned dendritic cells induce humoral tolerance to protein therapy in mice

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12 December 2020

Immunogenicity and tolerability of an investigational formulation of interferon-β1a: 24- and 48-week interim analyses of a 2-year, single-arm, historically controlled, phase IIIb study in adults with multiple sclerosis

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12 December 2020

Tolerance induction by exosomes from immature dendritic cells and rapamycin in a mouse cardiac allograft model

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12 December 2020

Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies.

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12 December 2020

Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production

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12 December 2020

Considerations for optimization and validation of an in vitro PBMC derived T cell assay for immunogenicity prediction of biotherapeutics

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12 December 2020

The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

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12 December 2020

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

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12 December 2020

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells.

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12 December 2020

Effects of mycophenolate mofetil on donor-specific antibody formation in renal transplantation

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12 December 2020

Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T cells

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12 December 2020

Minimizing immunogenicity of biopharmaceuticals by controlling critical quality attributes of proteins

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12 December 2020

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12 December 2020

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12 December 2020

Effects of protein aggregates: an immunologic perspective

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12 December 2020

Immunogenicity of Therapeutic Protein Aggregates

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12 December 2020

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12 December 2020

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12 December 2020

The multiple facets of mTOR in immunity.

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12 December 2020

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12 December 2020

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12 December 2020

Successful induction of immune tolerance to enzyme replacement therapy in canine mucopolysaccharidosis I

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12 December 2020

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12 December 2020

Methotrexate reduces antibody responses to recombinant human alpha-galactosidase A therapy in a mouse model of Fabry disease

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12 December 2020

Dendritic cells in intestinal immune regulation.

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12 December 2020

Assessment of the immunogenicity of different interferon beta-1a formulations using ex vivo T-cell assays

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12 December 2020

Antigen administration by continuous feeding enhances oral tolerance and leads to long-lasting effects

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12 December 2020

How we treat a hemophilia A patient with a factor VIII inhibitor

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12 December 2020

Exposure to factor VIII protein in the presence of phosphatidylserine induces hypo-responsiveness toward factor VIII challenge in hemophilia A mice

1 reference

12 December 2020

Engineered binding to erythrocytes induces immunological tolerance to E. coli asparaginase

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12 December 2020