(Q41353938)

English

Physical characterization and in vitro biological impact of highly aggregated antibodies separated into size-enriched populations by fluorescence-activated cell sorting

scientific article published on 5 March 2015

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Physical characterization and in vitro biological impact of highly aggregated antibodies separated into size-enriched populations by fluorescence-activated cell sorting (English)

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

author name string

Srivalli Telikepalli

1

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Heather E Shinogle

2

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Prem S Thapa

3

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Jae Hyun Kim

4

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Meghana Deshpande

5

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Vibha Jawa

6

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

C Russell Middaugh

7

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Linda O Narhi

8

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Marisa K Joubert

9

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

David B Volkin

10

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

language of work or name

0 references

publication date

5 March 2015

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Europe PubMed Central

PMC publication ID

29 September 2017

Journal of Pharmaceutical Sciences

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Europe PubMed Central

PMC publication ID

29 September 2017

104

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

5

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

1575-1591

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

Calculating the mass of subvisible protein particles with improved accuracy using microflow imaging data

1 reference

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Freezing-induced perturbation of tertiary structure of a monoclonal antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

UV photodegradation of murine growth hormone: chemical analysis and immunogenicity consequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Aggregation of human recombinant monoclonal antibodies influences the capacity of dendritic cells to stimulate adaptive T-cell responses in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Structural characterization of IgG1 mAb aggregates and particles generated under various stress conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Radar chart array analysis to visualize effects of formulation variables on IgG1 particle formation as measured by multiple analytical techniques

1 reference

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1 October 2017

Ultraviolet spectroscopy as a tool in therapeutic protein development.

1 reference

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1 October 2017

Immunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice

1 reference

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1 October 2017

Improved data visualization techniques for analyzing macromolecule structural changes

1 reference

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1 October 2017

Compatibility, physical stability, and characterization of an IgG4 monoclonal antibody after dilution into different intravenous administration bags

1 reference

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1 October 2017

Highly aggregated antibody therapeutics can enhance the in vitro innate and late-stage T-cell immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Immunogenicity of protein aggregates--concerns and realities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Immunogenicity of therapeutic proteins: the use of animal models

1 reference

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1 October 2017

Oxidized and aggregated recombinant human interferon beta is immunogenic in human interferon beta transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Immunogenicity of protein therapeutics: The key causes, consequences and challenges

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Classification and characterization of therapeutic antibody aggregates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

In vitro immunogenicity risk assessment of therapeutic proteins in preclinical setting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Comparative Effects of pH and Ionic Strength on Protein–Protein Interactions, Unfolding, and Aggregation for IgG1 Antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

How to systematically evaluate immunogenicity of therapeutic proteins - regulatory considerations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

New approaches to prediction of immune responses to therapeutic proteins during preclinical development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Protein aggregation: pathways, induction factors and analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Development of a maturing T-cell-mediated immune response in patients with idiopathic Parkinson's disease receiving r-metHuGDNF via continuous intraputaminal infusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Immunogenicity of therapeutic proteins. Part 2: impact of container closures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Downstream processing of monoclonal antibodies--application of platform approaches

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Protein aggregation and bioprocessing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Structural characterization and immunogenicity in wild-type and immune tolerant mice of degraded recombinant human interferon alpha2b.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Factors influencing the immunogenicity of therapeutic proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

What is antibody-mediated pure red cell aplasia (PRCA)?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Protein aggregation and its inhibition in biopharmaceutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Challenges in the development of high protein concentration formulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Minimizing the immunogenicity of protein therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Immunogenicity of therapeutic proteins: clinical implications and future prospects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

1 October 2017

Tolerance induced by physiological levels of secreted proteins in transgenic mice expressing human insulin

1 reference

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1 October 2017

Models for evaluation of relative immunogenic potential of protein particles in biopharmaceutical protein formulations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

11 June 2018

Chemical modifications in therapeutic protein aggregates generated under different stress conditions

1 reference

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11 June 2018

Flow cytometry: a promising technique for the study of silicone oil-induced particulate formation in protein formulations

1 reference

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11 June 2018

Transgenic mice as a model to test the immunogenicity of proteins altered by site-specific mutagenesis

1 reference

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Conformational stability, reversibility and heat-induced aggregation of α-1-acid glycoprotein

1 reference

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Renewal of the air-water interface as a critical system parameter of protein stability: aggregation of the human growth hormone and its prevention by surface-active compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

19 August 2018

Development of a human antibody tolerant mouse model to assess the immunogenicity risk due to aggregated biotherapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

19 August 2018

Size fractionation of microscopic protein aggregates using a preparative fluorescence-activated cell sorter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

19 August 2018

Classification of protein aggregates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

19 August 2018

The use of flow cytometry for the detection of subvisible particles in therapeutic protein formulations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

19 August 2018

Immunogenicity of biologically-derived therapeutics: assessment and interpretation of nonclinical safety studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

19 August 2018

Clinical validation of the "in silico" prediction of immunogenicity of a human recombinant therapeutic protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4448733

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1 reference

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1 reference

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19 August 2018

Thioflavin-S staining coupled to flow cytometry. A screening tool to detect in vivo protein aggregation

1 reference

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2 December 2018

Label-free flow cytometry analysis of subvisible aggregates in liquid IgG1 antibody formulations

1 reference

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12 December 2020

based on heuristic

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Immunogenicity of aggregates of recombinant human growth hormone in mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/25753756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of aggregated human growth hormone (hGH) in development of antibodies to hGH

1 reference

https://pubmed.ncbi.nlm.nih.gov/25753756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunogenicity of recombinant human interferon beta interacting with particles of glass, metal, and polystyrene

1 reference

https://pubmed.ncbi.nlm.nih.gov/25753756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody Response to Aggregated Human Interferon Alpha2b in Wild-type and Transgenic Immune Tolerant Mice Depends on Type and Level of Aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25753756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TOLERANCE TO A PROTEIN ANTIGEN IN ADULT MICE AND THE EFFECT OF NONSPECIFIC FACTORS

1 reference

https://pubmed.ncbi.nlm.nih.gov/25753756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein aggregates seem to play a key role among the parameters influencing the antigenicity of interferon alpha (IFN-alpha) in normal and transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25753756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat denaturation, a simple method to improve the immunotherapeutic potential of allergens

1 reference

https://pubmed.ncbi.nlm.nih.gov/25753756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of soluble aggregates in the primary immune response of mice to human gamma globulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/25753756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Considerations for optimization and validation of an in vitro PBMC derived T cell assay for immunogenicity prediction of biotherapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/25753756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glass particles as an adjuvant: a model for adverse immunogenicity of therapeutic proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/25753756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of the immunogenicity of different interferon beta-1a formulations using ex vivo T-cell assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/25753756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/JPS.24379

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

29 September 2017

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