(Q39029239)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24476626%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24476626%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

12

1 reference

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6 March 2020

author name string

Changjie Wu

1

1 reference

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6 March 2020

Sunquan Qiu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24476626%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Liting Lu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24476626%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Jiawei Zou

4

1 reference

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6 March 2020

Wen-feng Li

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24476626%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Ouchen Wang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24476626%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Haina Zhao

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24476626%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Hongxiao Wang

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24476626%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Jiajia Tang

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24476626%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Lin Chen

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24476626%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Tao Xu

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24476626%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

Wanqin Liao

13

1 reference

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6 March 2020

Guangbin Luo

14

1 reference

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6 March 2020

Xincheng Lu

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24476626%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

language of work or name

English

0 references

publication date

1 January 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24476626%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24476626%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

volume

5

1 reference

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6 March 2020

page(s)

3149

1 reference

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https://scigraph.springernature.com/pub.10.1038/ncomms4149

6 March 2020

exact match

0 references

cites work

Cancer statistics, 2007

1 reference

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Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.

21 January 2018

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Wnt/beta-catenin signaling: components, mechanisms, and diseases

21 January 2018

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APC, signal transduction and genetic instability in colorectal cancer

21 January 2018

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Comprehensive molecular characterization of human colon and rectal cancer

21 January 2018

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Cellular signaling and biological functions of R-spondins

21 January 2018

1 reference

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The R-spondin protein family

21 January 2018

1 reference

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R-Spondin proteins: a novel link to beta-catenin activation

21 January 2018

1 reference

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R-Spondin family members regulate the Wnt pathway by a common mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

21 January 2018

1 reference

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R-spondin1 is essential in sex determination, skin differentiation and malignancy.

21 January 2018

1 reference

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Mitogenic influence of human R-spondin1 on the intestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

R-spondin3 is required for mouse placental development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

Thrombospondins and novel TSR-containing proteins, R-spondins, regulate bone formation and remodeling

21 January 2018

1 reference

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R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

A WNT/beta-catenin signaling activator, R-spondin, plays positive regulatory roles during skeletal myogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer.

21 January 2018

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Wnt signaling and Dupuytren's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

Craniofacial malformation in R-spondin2 knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis

21 January 2018

1 reference

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Secreted factor R-Spondin 2 is involved in refinement of patterning of the mammalian cochlea.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb

21 January 2018

1 reference

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A new common integration site, Int7, for the mouse mammary tumor virus in mouse mammary tumors identifies a gene whose product has furin-like and thrombospondin-like sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

Recurrent R-spondin fusions in colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

Epigenetic regulation and colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

The Intestinal Wnt/TCF Signature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4149

LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4149

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

21 January 2018

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Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4149

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

21 January 2018

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Regulation of Lrp6 phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4149

LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signaling

21 January 2018

1 reference

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ZNRF3 acts as a tumour suppressor by the Wnt signalling pathway in human gastric adenocarcinoma

21 January 2018

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The structural basis of R-spondin recognition by LGR5 and RNF43

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS4149

Structural basis for R-spondin recognition by LGR4/5/6 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5

21 January 2018

1 reference

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Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo

21 January 2018

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Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia.

21 January 2018

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The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers

21 January 2018

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Colorectal cancer screening: prospects for molecular stool analysis

21 January 2018

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Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity

21 January 2018

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Overexpression of a novel osteopetrosis-related gene CCDC154 suppresses cell proliferation by inducing G2/M arrest

21 January 2018

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Anticancer activity of 2α, 3α, 19β, 23β-Tetrahydroxyurs-12-en-28-oic acid (THA), a novel triterpenoid isolated from Sinojackia sarcocarpa

21 January 2018

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R-spondin2 expression in the apical ectodermal ridge is essential for outgrowth and patterning in mouse limb development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149

inferred from DOI database lookup

7 January 2021

based on heuristic

Corneal endothelial cell fate is maintained by LGR5 through the regulation of hedgehog and Wnt pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4149