(Q39032580)

8 September 2017

title

Efficacy of cyclin-dependent-kinase 9 inhibitors in a murine model of mixed-lineage leukemia (English)

1 reference

8 September 2017

1 reference

1 reference

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24445865%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

M-P Garcia-Cuellar

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24445865%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

E Füller

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24445865%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

E Mäthner

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24445865%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

C Breitinger

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24445865%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

K Hetzner

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24445865%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

L Zeitlmann

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24445865%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

A Borkhardt

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24445865%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

publication date

21 January 2014

1 reference

8 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24445865%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24445865%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24445865%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

1427-1435

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24445865%20AND%20SRC:MED&resulttype=core&format=json

Prognostic factors in adult patients up to 60 years old with acute myeloid leukemia and translocations of chromosome band 11q23: individual patient data-based meta-analysis of the German Acute Myeloid Leukemia Intergroup

1 June 2020

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The molecular biology of mixed lineage leukemia

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AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia

21 January 2018

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A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification

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Misguided transcriptional elongation causes mixed lineage leukemia

21 January 2018

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A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

21 January 2018

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Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

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Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

21 January 2018

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Controlling the elongation phase of transcription with P-TEFb

21 January 2018

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Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

21 January 2018

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MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells

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Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

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Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

21 January 2018

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

21 January 2018

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

21 January 2018

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 January 2018

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Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.

21 January 2018

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DNA damage response and inflammatory signaling limit the MLL-ENL-induced leukemogenesis in vivo.

21 January 2018

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

21 January 2018

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Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein

21 January 2018

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MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

21 January 2018

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Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

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RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction

21 January 2018

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Selective inhibition of tumor oncogenes by disruption of super-enhancers

21 January 2018

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Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiation

21 January 2018

1 reference

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Caffeine prevents transcription inhibition and P-TEFb/7SK dissociation following UV-induced DNA damage

21 January 2018

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A dose-finding, pharmacokinetic and pharmacodynamic study of a novel schedule of flavopiridol in patients with advanced solid tumors

21 January 2018

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Flavopiridol: Judged by the company one keeps

21 January 2018

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