(Q39032624)

8 September 2017

title

Differential parsing of EGFR endocytic flux among parallel internalization pathways in lung cancer cells with EGFR-activating mutations (English)

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8 September 2017

Alice M Walsh

1

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8 September 2017

Matthew J Lazzara

series ordinal

2

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8 September 2017

publication date

21 January 2014

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8 September 2017

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8 September 2017

volume

6

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8 September 2017

issue

3

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8 September 2017

page(s)

312-323

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Endocytosis and signalling: intertwining molecular networks

8 September 2017

cites work

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https://api.crossref.org/works/10.1039%2FC3IB40176F

Derailed endocytosis: an emerging feature of cancer

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Endocytosis and intracellular trafficking of ErbBs

21 January 2018

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The Cbl interactome and its functions

21 January 2018

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Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

21 January 2018

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Feedback inhibition by RALT controls signal output by the ErbB network

21 January 2018

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A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation.

21 January 2018

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Mig-6 controls EGFR trafficking and suppresses gliomagenesis

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Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface

21 January 2018

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Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation

21 January 2018

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Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops

21 January 2018

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Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3IB40176F

Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation

21 January 2018

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Decreased internalisation of erbB1 mutants in lung cancer is linked with a mechanism conferring sensitivity to gefitinib

21 January 2018

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Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis.

21 January 2018

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A steady state model for analyzing the cellular binding, internalization and degradation of polypeptide ligands

21 January 2018

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Mathematical model for the effects of epidermal growth factor receptor trafficking dynamics on fibroblast proliferation responses

21 January 2018

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Computational analysis of the regulation of EGFR by protein tyrosine phosphatases

21 January 2018

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Regulation of EGFR trafficking and cell signaling by Sprouty2 and MIG6 in lung cancer cells

21 January 2018

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Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations

21 January 2018

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Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors.

21 January 2018

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Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized

21 January 2018

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

21 January 2018

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

21 January 2018

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Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop

21 January 2018

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Kinetics of protein-protein association explained by Brownian dynamics computer simulation

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3IB40176F

Diminished functional role and altered localization of SHP2 in non-small cell lung cancer cells with EGFR-activating mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3IB40176F

Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3IB40176F

Signaling networks assembled by oncogenic EGFR and c-Met

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3IB40176F

HER2-Mediated Effects on EGFR Endosomal Sorting: Analysis of Biophysical Mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3IB40176F

Mechanistic insights into the activation of oncogenic forms of EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3IB40176F

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3IB40176F

Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3IB40176F

Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3IB40176F

21 January 2018

Identifiers

DOI

10.1039/C3IB40176F

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8 September 2017

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