(Q37307506)

19 August 2017

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title

Derailed endocytosis: an emerging feature of cancer (English)

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19 August 2017

2

Gordon B Mills

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19 August 2017

Yaron Mosesson

1

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19 August 2017

Yosef Yarden

series ordinal

3

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19 August 2017

language of work or name

English

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publication date

1 November 2008

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19 August 2017

published in

Nature Reviews Cancer

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19 August 2017

volume

8

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19 August 2017

issue

11

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19 August 2017

page(s)

835-850

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19 August 2017

cites work

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Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

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Clathrin-independent endocytosis of ubiquitinated cargos

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Expression of Mutant Dynamin Inhibits Toxicity and Transport of Endocytosed Ricin to the Golgi Apparatus

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Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin

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Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway

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ARF1 is directly involved in dynamin-independent endocytosis

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Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes

31 March 2020

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A novel endocytic mechanism of epidermal growth factor receptor sequestration and internalization

31 March 2020

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Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases

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Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3.

31 March 2020

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Polarized epithelial membrane traffic: conservation and plasticity

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Clathrin is a key regulator of basolateral polarity.

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Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic

31 March 2020

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A Genetic Screen in Drosophila for Metastatic Behavior

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A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells

31 March 2020

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JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin

31 March 2020

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Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer

31 March 2020

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Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

31 March 2020

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Structurally conserved interaction of Lgl family with SNAREs is critical to their cellular function

31 March 2020

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Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis

31 March 2020

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Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.

31 March 2020

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Expression of Hugl-1 is strongly reduced in malignant melanoma

31 March 2020

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Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling

31 March 2020

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Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control

31 March 2020

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The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.

31 March 2020

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Convergence of Wnt, beta-catenin, and cadherin pathways

31 March 2020

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Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion.

31 March 2020

1 reference

Involvement of the Ras-Ras-activated Rab5 guanine nucleotide exchange factor RIN2-Rab5 pathway in the hepatocyte growth factor-induced endocytosis of E-cadherin

31 March 2020

1 reference

EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin

31 March 2020

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Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex

31 March 2020

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VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin

31 March 2020

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Inhibition of tumor growth and metastasis by depletion of vesicular sorting protein Hrs: its regulatory role on E-cadherin and beta-catenin.

31 March 2020

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Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.

31 March 2020

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GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.

31 March 2020

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The N-Myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin

31 March 2020

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E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function

31 March 2020

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Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland

31 March 2020

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p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions

31 March 2020

1 reference

Role of p120-catenin in cadherin trafficking

31 March 2020

1 reference

Decreased expression of catenins (alpha and beta), p120 CTN, and E-cadherin cell adhesion proteins and E-cadherin gene promoter methylation in prostatic adenocarcinomas

31 March 2020

1 reference

Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease

31 March 2020

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A module of negative feedback regulators defines growth factor signaling

31 March 2020

1 reference

Computational modeling of the EGF-receptor system: a paradigm for systems biology

31 March 2020

1 reference

Untangling the ErbB signalling network

31 March 2020

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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

31 March 2020

1 reference

Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes

31 March 2020

1 reference

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

31 March 2020

1 reference

Keratinocyte growth factor receptor ligands target the receptor to different intracellular pathways.

31 March 2020

1 reference

EGFR and cancer prognosis

31 March 2020

1 reference

Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers

31 March 2020

1 reference

ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors.

31 March 2020

1 reference

Association with membrane protrusions makes ErbB2 an internalization-resistant receptor

31 March 2020

1 reference

Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation

31 March 2020

1 reference

Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.

31 March 2020

1 reference

Geldanamycin induces ErbB-2 degradation by proteolytic fragmentation

31 March 2020

1 reference

The Her-2/neu gene and protein in breast cancer 2003: biomarker and target of therapy

31 March 2020

1 reference

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

31 March 2020

1 reference

Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases

31 March 2020

1 reference

Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

31 March 2020

1 reference

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

31 March 2020

1 reference

Flt3-dependent transformation by inactivating c-Cbl mutations in AML

31 March 2020

1 reference

E3-independent monoubiquitination of ubiquitin-binding proteins.

31 March 2020

1 reference

EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes

31 March 2020

1 reference

Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII.

31 March 2020

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Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling.

31 March 2020

1 reference

Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors

31 March 2020

1 reference

Epidermal growth factor receptor exposed to cigarette smoke is aberrantly activated and undergoes perinuclear trafficking

31 March 2020

1 reference

Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation

31 March 2020

1 reference

Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl).

31 March 2020

1 reference

Src promotes destruction of c-Cbl: implications for oncogenic synergy between Src and growth factor receptors

31 March 2020

1 reference

Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation

31 March 2020

1 reference

Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins

31 March 2020

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Mechanism of biological synergy between cellular Src and epidermal growth factor receptor

31 March 2020

1 reference

Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH.

31 March 2020

1 reference

WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation

31 March 2020

1 reference

Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor Degradation

31 March 2020

1 reference

Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters

31 March 2020

1 reference

hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl

31 March 2020

1 reference

Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops

31 March 2020

1 reference

The ras/mitogen-activated protein kinase pathway inhibitor and likely tumor suppressor proteins, sprouty 1 and sprouty 2 are deregulated in breast cancer.

31 March 2020

1 reference

The expression of Sprouty1, an inhibitor of fibroblast growth factor signal transduction, is decreased in human prostate cancer.

31 March 2020

1 reference

Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits

31 March 2020

1 reference

A pathway for association of receptors, adaptors, and actin during endocytic internalization.

31 March 2020

1 reference

HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain

31 March 2020

1 reference

RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery

31 March 2020

1 reference

Huntingtin interacting protein 1 is a novel brain tumor marker that associates with epidermal growth factor receptor.

31 March 2020

1 reference

Altered receptor trafficking in Huntingtin Interacting Protein 1-transformed cells.

31 March 2020

1 reference

Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor

31 March 2020

1 reference

Isolation of yeast mutants defective in protein targeting to the vacuole

31 March 2020

1 reference

Overproduction-induced mislocalization of a yeast vacuolar protein allows isolation of its structural gene

31 March 2020

1 reference

Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants

31 March 2020

1 reference

Receptor downregulation and multivesicular-body sorting

31 March 2020

1 reference

The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.

31 March 2020

1 reference

Depletion of TSG101 forms a mammalian "Class E" compartment: a multicisternal early endosome with multiple sorting defects.

31 March 2020

1 reference

Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth

31 March 2020

1 reference

Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila

31 March 2020

1 reference

The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking

31 March 2020

1 reference

Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells

31 March 2020

1 reference

Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues

31 March 2020

1 reference

Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells

31 March 2020

1 reference

Reduction of TSG101 protein has a negative impact on tumor cell growth

31 March 2020

1 reference

Tsg101 is upregulated in a subset of invasive human breast cancers and its targeted overexpression in transgenic mice reveals weak oncogenic properties for mammary cancer initiation

31 March 2020

1 reference

HCRP1, a novel gene that is downregulated in hepatocellular carcinoma, encodes a growth-inhibitory protein

31 March 2020

1 reference

Endocytic recycling pathways: emerging regulators of cell migration.

31 March 2020

1 reference

Real-time analysis of clathrin-mediated endocytosis during cell migration

31 March 2020

1 reference

PDGF-regulated rab4-dependent recycling of alphavbeta3 integrin from early endosomes is necessary for cell adhesion and spreading

31 March 2020

1 reference

Endocytosis and nuclear trafficking of adeno-associated virus type 2 are controlled by rac1 and phosphatidylinositol-3 kinase activation

31 March 2020

1 reference

Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase

31 March 2020

1 reference

FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation

31 March 2020

1 reference

Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3.

31 March 2020

1 reference

Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization.

31 March 2020

1 reference

Endocytic transport of integrins during cell migration and invasion.

31 March 2020

1 reference

PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility

31 March 2020

1 reference

An ACAP1-containing clathrin coat complex for endocytic recycling

31 March 2020

1 reference

Stimulation-dependent recycling of integrin beta1 regulated by ARF6 and Rab11.

31 March 2020

1 reference

Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins

31 March 2020

1 reference

Integrins: bidirectional, allosteric signaling machines

31 March 2020

1 reference

Adhesion events in angiogenesis.

31 March 2020

1 reference

Overexpression of the alpha v beta 6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival

31 March 2020

1 reference

HS1-Associated Protein X-1 Regulates Carcinoma Cell Migration and Invasion via Clathrin-Mediated Endocytosis of Integrin αvβ6

31 March 2020

1 reference

The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers

31 March 2020

1 reference

The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program.

31 March 2020

1 reference

Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments

31 March 2020

1 reference

A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes

31 March 2020

1 reference

Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin

31 March 2020

1 reference

Emerging role of RAB GTPases in cancer and human disease

31 March 2020

1 reference

Molecular analysis of transitional cell carcinoma using cDNA microarray

31 March 2020

1 reference

Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration

31 March 2020

1 reference

Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion

31 March 2020

1 reference

EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells

31 March 2020

1 reference

Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis

31 March 2020

1 reference

Hypoxic gene expression and metastasis

31 March 2020

1 reference

Cisplatin induces PKB/Akt activation and p38(MAPK) phosphorylation of the EGF receptor

31 March 2020

1 reference

p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy

31 March 2020

1 reference

Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis

31 March 2020

1 reference

The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex

31 March 2020

1 reference

Cancer therapeutic antibodies come of age: targeting minimal residual disease

31 March 2020

1 reference

Synergistic down-regulation of receptor tyrosine kinases by combinations of mAbs: implications for cancer immunotherapy

31 March 2020

1 reference

Control of EGF receptor signaling by clathrin-mediated endocytosis.

31 March 2020

1 reference

Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction

31 March 2020

1 reference

Stimulation of cell proliferation by endosomal epidermal growth factor receptor as revealed through two distinct phases of signaling

31 March 2020

1 reference

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

31 March 2020

1 reference

Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain

31 March 2020

1 reference

The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone

31 March 2020

1 reference

Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1.

31 March 2020

1 reference

Effective intravenous therapy of murine pulmonary metastases with an oncolytic herpes virus expressing interleukin 12

31 March 2020

1 reference

Requirement of clathrin heavy chain for p53-mediated transcription

31 March 2020

1 reference

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

31 March 2020

1 reference

Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias

31 March 2020

1 reference

Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia

31 March 2020

1 reference

Overexpression of βPix-a in human breast cancer tissues

31 March 2020

1 reference

Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor

31 March 2020

1 reference

A novel CLTC-TFE3 gene fusion in pediatric renal adenocarcinoma with t(X;17)(p11.2;q23).

31 March 2020

1 reference

The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family

31 March 2020

1 reference

Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias

31 March 2020

1 reference

Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein

31 March 2020

1 reference

Sprouty and cancer: the first terms report.

31 March 2020

1 reference

Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder

31 March 2020

1 reference

NUMB controls p53 tumour suppressor activity

31 March 2020

1 reference

Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1

31 March 2020

1 reference

Down-regulated expression of atypical PKC-binding domain deleted asip isoforms in human hepatocellular carcinomas

31 March 2020

1 reference

Caveolin-1: a tumor-promoting role in human cancer

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC2521

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19 August 2017

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