(Q39035070)

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Roflumilast N-oxide prevents cytokine secretion induced by cigarette smoke combined with LPS through JAK/STAT and ERK1/2 inhibition in airway epithelial cells.

scientific article published on 8 January 2014

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24416369%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Roflumilast N-oxide prevents cytokine secretion induced by cigarette smoke combined with LPS through JAK/STAT and ERK1/2 inhibition in airway epithelial cells (English)

1 reference

Europe PubMed Central

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5 March 2020

Manuella Lanzetti

3

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5 March 2020

Luis Cristovão Sobrino Porto

6

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5 March 2020

author name string

Tatiana Victoni

1

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5 March 2020

Florence Gleonnec

2

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5 March 2020

Hermann Tenor

4

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5 March 2020

Samuel Valença

5

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5 March 2020

Vincent Lagente

7

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5 March 2020

Elisabeth Boichot

8

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5 March 2020

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8 January 2014

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5 March 2020

1 reference

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5 March 2020

9

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5 March 2020

1

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5 March 2020

e85243

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5 March 2020

copyright license

Creative Commons Attribution 4.0 International

8 January 2014

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April 2022 Public Data File from Crossref

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Roflumilast, a Novel Phosphodiesterase 4 Inhibitor, for COPD Patients with a History of Exacerbations.

1 reference

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9 September 2017

Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide

1 reference

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9 September 2017

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9 September 2017

MAPK signaling pathways regulate IL-8 mRNA stability and IL-8 protein expression in cystic fibrosis lung epithelial cell lines

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9 September 2017

Treatment of chronic obstructive pulmonary disease with roflumilast, a new phosphodiesterase 4 inhibitor

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9 September 2017

The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

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9 September 2017

The cytokine network in chronic obstructive pulmonary disease

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Emerging role of MAP kinase pathways as therapeutic targets in COPD.

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9 September 2017

The epidermal growth factor receptor pathway: a model for targeted therapy

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9 September 2017

Interleukin (IL)-4 and IL-13 up-regulate monocyte chemoattractant protein-1 expression in human bronchial epithelial cells: involvement of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2 and Janus kinase-2 but not c-J

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9 September 2017

Kinase inhibitors and airway inflammation.

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9 September 2017

Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells.

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9 September 2017

Chemokines in bronchiolar epithelium in the development of chronic obstructive pulmonary disease.

1 reference

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9 September 2017

The nature of small-airway obstruction in chronic obstructive pulmonary disease

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9 September 2017

Mechanism of cigarette smoke condensate-induced acute inflammatory response in human bronchial epithelial cells

1 reference

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9 September 2017

Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations

1 reference

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9 September 2017

Reactive oxygen species mediate Jak2/Stat3 activation and IL-8 expression in pulmonary epithelial cells stimulated with lipid-associated membrane proteins from Mycoplasma pneumoniae

1 reference

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9 September 2017

Galactose specific adhesin of enteroaggregative E. coli induces IL-8 secretion via activation of MAPK and STAT-3 in INT-407 cells

1 reference

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14 September 2017

Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885699

14 September 2017

Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885699

14 September 2017

Cigarette smoke inhibits lipopolysaccharide-induced production of inflammatory cytokines by suppressing the activation of activator protein-1 in bronchial epithelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885699

14 September 2017

Src family protein tyrosine kinase signaling mediates monosodium urate crystal-induced IL-8 expression by monocytic THP-1 cells

1 reference

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25 September 2017

Activation of extracellular signal-regulated kinase by ultraviolet is mediated through Src-dependent epidermal growth factor receptor phosphorylation. Its implication in an anti-apoptotic function

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25 September 2017

Cigarette smoke-induced Egr-1 upregulates proinflammatory cytokines in pulmonary epithelial cells.

1 reference

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17 June 2018

Primary human alveolar type II epithelial cell chemokine release: effects of cigarette smoke and neutrophil elastase

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17 June 2018

Predisposing factors to bacterial colonization in chronic obstructive pulmonary disease.

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17 June 2018

Phosphodiesterase isozymes: molecular targets for novel antiasthma agents

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17 June 2018

Epidermal‐Growth‐Factor‐Dependent Activation of the Src‐Family Kinases

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17 June 2018

Src tyrosine kinase inhibition prevents pulmonary ischemia-reperfusion-induced acute lung injury.

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21 August 2018

A phosphodiesterase 4 inhibitor, roflumilast N-oxide, inhibits human lung fibroblast functions in vitro.

1 reference

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21 August 2018

Direct effect of cigarette smoke on human pulmonary artery tension

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21 August 2018

Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke

1 reference

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Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kappaB activation and proinflammatory cytokine release in alveolar epithelial cells

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21 August 2018

Autocrine ligands for the epidermal growth factor receptor mediate interleukin-8 release from bronchial epithelial cells in response to cigarette smoke

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21 August 2018

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21 August 2018

Infections and Airway Inflammation in Chronic Obstructive Pulmonary Disease Severe Exacerbations

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21 January 2018

Chronic obstructive pulmonary disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24416369

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of cigarette smoke extract on nitric oxide synthase in pulmonary artery endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24416369

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alveolar cell senescence exacerbates pulmonary inflammation in patients with chronic obstructive pulmonary disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24416369

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhalation of LPS induces inflammatory airway responses mimicking characteristics of chronic obstructive pulmonary disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24416369

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GRO-alpha regulation in airway smooth muscle by IL-1beta and TNF-alpha: role of NF-kappaB and MAP kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/24416369

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0085243

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5 March 2020

2014PLoSO...985243V

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1 reference

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5 March 2020

1 reference

Europe PubMed Central

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5 March 2020

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