(Q39037669)

English

Substrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles

scientific article published on 14 November 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

Substrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles (English)

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

Mycobacterium tuberculosis

0 references

bicyclic nitroimidazole

1 reference

ChEBI release 2020-05-28

object named as

Joseph Cherian

9

0 references

object named as

Thomas Dick

11

0 references

Clifton E Barry

object named as

Clifton E Barry

12

0 references

author name string

Meera Gurumurthy

1

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

Tathagata Mukherjee

2

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

Cynthia S Dowd

3

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

Ramandeep Singh

4

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

Pornwaratt Niyomrattanakit

5

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

Jo Ann Tay

6

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

Amit Nayyar

7

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

Yong Sok Lee

8

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

Helena I Boshoff

10

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

Ujjini H Manjunatha

13

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

language of work or name

0 references

publication date

14 November 2011

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

279

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

1

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

113-125

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

Identification and characterization of two families of F420H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

The mechanism of action of PA-824: Novel insights from transcriptional profiling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Conversion of NO2 to NO by reduced coenzyme F420 protects mycobacteria from nitrosative damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Confronting the scientific obstacles to global control of tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

New methods for efficient protein production in drug discovery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Multidrug-resistant tuberculosis: a menace that threatens to destabilize tuberculosis control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Immunogenic membrane-associated proteins of Mycobacterium tuberculosis revealed by proteomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Prospects for clinical introduction of nitroimidazole antibiotics for the treatment of tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Large-scale production of coenzyme F420-5,6 by using Mycobacterium smegmatis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Demonstration that fbiC is required by Mycobacterium bovis BCG for coenzyme F(420) and FO biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Use of transposon Tn5367 mutagenesis and a nitroimidazopyran-based selection system to demonstrate a requirement for fbiA and fbiB in coenzyme F(420) biosynthesis by Mycobacterium bovis BCG

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Why metronidazole is active against both bacteria and parasites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

In vitro and in vivo activities of the nitroimidazole CGI 17341 against Mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Distribution of coenzyme F420 and properties of its hydrolytic fragments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

9 September 2017

Effect of malaria infection and endotoxin-induced fever on the metabolism of antipyrine and metronidazole in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

25 September 2017

A new role for coenzyme F420 in aflatoxin reduction by soil mycobacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

17 June 2018

Synthesis and structure-activity studies of biphenyl analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

21 August 2018

Structures of coenzyme F(420) in Mycobacterium species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444742

21 August 2018

Nitroaromatic compounds, from synthesis to biodegradation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08404.X

21 January 2018

Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08404.X

21 January 2018

Synthesis and Structure−Activity Relationships of Aza- and Diazabiphenyl Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08404.X

21 January 2018

Synthesis and antituberculosis activity of a novel series of optically active 6-nitro-2,3-dihydroimidazo[2,1-b]oxazoles

1 reference

https://pubmed.ncbi.nlm.nih.gov/22023140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and structure-activity relationships of antitubercular 2-nitroimidazooxazines bearing heterocyclic side chains

1 reference

https://pubmed.ncbi.nlm.nih.gov/22023140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proposed structure for coenzyme F420 from Methanobacterium

1 reference

https://pubmed.ncbi.nlm.nih.gov/22023140

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1742-4658.2011.08404.X

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

8 September 2017

ResearchGate publication ID

0 references

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