(Q39042555)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24345760%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

Tyk2 is a therapeutic target for psoriasis-like skin inflammation (English)

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3 March 2020

0 references

2

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3 March 2020

Yuichi Sekine

4

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3 March 2020

author name string

Masayuki Ishizaki

1

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3 March 2020

Toshihiko Akimoto

3

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3 March 2020

Shigeyuki Kon

5

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3 March 2020

Manish Diwan

6

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3 March 2020

Hiroaki Maeda

7

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3 March 2020

Sumihito Togi

8

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3 March 2020

Kazuya Shimoda

9

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3 March 2020

Kenji Oritani

10

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3 March 2020

Tadashi Matsuda

11

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3 March 2020

publication date

17 December 2013

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3 March 2020

published in

International Immunology

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3 March 2020

volume

26

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3 March 2020

issue

5

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3 March 2020

page(s)

257-267

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Cytokine receptor signalling

3 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Partial impairment of cytokine responses in Tyk2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Cutting edge: tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-alpha-induced suppression of B lymphocyte formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

A patient with tyrosine kinase 2 deficiency without hyper-IgE syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Pathogenesis and therapy of psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

The IL-23/Th17 axis in the immunopathogenesis of psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Th17 cells carrying TCR recognizing epidermal autoantigen induce psoriasis-like skin inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Differential requirements for JAK2 and TYK2 in T cell proliferation and IFN-gamma production induced by IL-12 alone or together with IL-18.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Tyrphostin AG490 agent modestly but significantly prevents onset of type 1 in NOD mouse; implication of immunologic and metabolic effects of a Jak-Stat pathway inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Sumoylation of Daxx regulates IFN-induced growth suppression of B lymphocytes and the hormone receptor-mediated transactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Expanding the roles of antimicrobial peptides in skin: alarming and arming keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Antimicrobial peptides in the pathogenesis of psoriasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

IL-22, a Th1 cytokine that targets the pancreas and select other peripheral tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Biology of interleukin-22.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Interleukin-17 and Interleukin-22 Induced Proinflammatory Cytokine Production in Keratinocytes via Inhibitor of Nuclear Factor κB Kinase-α Expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

IL-22 increases the innate immunity of tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Efficacy and safety of tofacitinib, an oral Janus kinase inhibitor, in the treatment of psoriasis: a Phase 2b randomized placebo-controlled dose-ranging study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Preliminary clinical activity of a topical JAK1/2 inhibitor in the treatment of psoriasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

Comprehensive review of JAK inhibitors in myeloproliferative neoplasms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT062

21 January 2018

Identifiers

DOI

10.1093/INTIMM/DXT062

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24345760%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference