(Q34969188)

5 August 2017

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title

The IL-23/Th17 axis in the immunopathogenesis of psoriasis (English)

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5 August 2017

Antonella Di Cesare

1

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5 August 2017

Paola Di Meglio

series ordinal

2

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5 August 2017

Frank O Nestle

series ordinal

3

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5 August 2017

language of work or name

English

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publication date

26 March 2009

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Journal of Investigative Dermatology

5 August 2017

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5 August 2017

129

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5 August 2017

6

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5 August 2017

1339-1350

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https://scigraph.springernature.com/pub.10.1038/jid.2009.59

5 August 2017

0 references

cites work

Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Interleukin 25 promotes the initiation of proallergic type 2 responses.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Serum levels of TNF-alpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiat

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

T(H)-17 cells in the circle of immunity and autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

T-helper 17 cells in psoriatic plaques and additional genetic links between IL-23 and psoriasis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

A role for T cell-derived interleukin 22 in psoriatic skin inflammation

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Predominance of "memory" T cells (CD4+, CDw29+) over "naive" T cells (CD4+, CD45R+) in both normal and diseased human skin

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibody.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

A phase 1/2A trial of STA 5326, an oral interleukin-12/23 inhibitor, in patients with active moderate to severe Crohn's disease

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Regulation of IL-17 production in human lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Distinct regulation of interleukin-17 in human T helper lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Cyclosporine A inhibits IL-15-induced IL-17 production in CD4+ T cells via down-regulation of PI3K/Akt and NF-kappaB.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Relation of an interleukin-23 receptor gene polymorphism to graft-versus-host disease after hematopoietic-cell transplantation

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis but not for systemic sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

CD69, HLA-DR and the IL-2R identify persistently activated T cells in psoriasis vulgaris lesional skin: blood and skin comparisons by flow cytometry.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Increased expression of interleukin 17 in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Alefacept therapy reduces the effector T-cell population in lesional psoriatic epidermis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

TNF Inhibition Rapidly Down-Regulates Multiple Proinflammatory Pathways in Psoriasis Plaques

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

A phase 1, double-blind, placebo-controlled study evaluating single subcutaneous administrations of a human interleukin-12/23 monoclonal antibody in subjects with plaque psoriasis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Insights into gene modulation by therapeutic TNF and IFNgamma antibodies: TNF regulates IFNgamma production by T cells and TNF-regulated genes linked to psoriasis transcriptome

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Identification of Cellular Pathways of "Type 1," Th17 T Cells, and TNF- and Inducible Nitric Oxide Synthase-Producing Dendritic Cells in Autoimmune Inflammation through Pharmacogenomic Study of Cyclosporine A in Psoriasis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Interleukin (IL)-23 receptor is a major susceptibility gene for Graves' ophthalmopathy: the IL-23/T-helper 17 axis extends to thyroid autoimmunity.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

3'UTR C2370A allele of the IL-23 receptor gene is associated with relapsing-remitting multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Microbial lipopeptides induce the production of IL-17 in Th cells.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Etanercept reduces the serum levels of interleukin-23 and macrophage inflammatory protein-3 alpha in patients with rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL-12, IL-23, and IL-27 enhance human beta-defensin-2 production in human keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

A Phase I Study Evaluating the Safety, Pharmacokinetics, and Clinical Response of a Human IL-12 p40 Antibody in Subjects with Plaque Psoriasis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Safety and efficacy of ABT-874, a fully human interleukin 12/23 monoclonal antibody, in the treatment of moderate to severe chronic plaque psoriasis: results of a randomized, placebo-controlled, phase 2 trial

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL-25 regulates Th17 function in autoimmune inflammation

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Possible Pathogenic Role of Th17 Cells for Atopic Dermatitis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Interleukin-17 gene expression in patients with rheumatoid arthritis.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: evidence for enhanced cutaneous immunity

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Increased interleukin-17 production in patients with systemic sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Psoriasis vulgaris: cutaneous lymphoid tissue supports T-cell activation and "Type 1" inflammatory gene expression

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Inducible IL-23p19 expression in human microglia via p38 MAPK and NF-kappaB signal pathways

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Transforming growth factor-beta induces development of the T(H)17 lineage

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Anti-interleukin-12 antibody for active Crohn's disease

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Stat3 and Stat4 direct development of IL-17-secreting Th cells.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Polymorphisms of the IL12B and IL23R genes are associated with psoriasis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

The IL-12 family member p40 chain as a master switch and novel therapeutic target in psoriasis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Antibodies to interleukin 12 abrogate established experimental colitis in mice

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Injection of pre-psoriatic skin with CD4+ T cells induces psoriasis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL23R: a susceptibility locus for celiac disease and multiple sclerosis?

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Differentiation of human TH-17 cells does require TGF-β!

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Regulation of virus-induced IL-12 and IL-23 expression in human macrophages

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Clinical improvement in chronic plaque-type psoriasis lesions after narrow-band UVB therapy is accompanied by a decrease in the expression of IFN-gamma inducers -- IL-12, IL-18 and IL-23

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Modulation of CLA, IL-12R, CD40L, and IL-2Ralpha expression and inhibition of IL-12- and IL-23-induced cytokine secretion by CNTO 1275

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

gammadelta T cells: an important source of IL-17.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

T cells involved in psoriasis vulgaris belong to the Th1 subset

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Suppression of ongoing disease in a nonhuman primate model of multiple sclerosis by a human-anti-human IL-12p40 antibody

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL-12/IL-23 in psoriasis.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Proinflammatory and immunoregulatory functions of interleukin-12.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Dominant lesional T cell receptor rearrangements persist in relapsing psoriasis but are absent from nonlesional skin: evidence for a stable antigen-specific pathogenic T cell response in psoriasis vulgaris

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL-17 family cytokines and the expanding diversity of effector T cell lineages

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Development, cytokine profile and function of human interleukin 17-producing helper T cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Cutting edge: immune cells as sources and targets of the IL-10 family members?

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Interleukin-22: a novel T- and NK-cell derived cytokine that regulates the biology of tissue cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Dermal injection of immunocytes induces psoriasis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL-21 and TGF-beta are required for differentiation of human T(H)17 cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

STAT3 regulates cytokine-mediated generation of inflammatory helper T cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Interleukin-17 and lung host defense against Klebsiella pneumoniae infection

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases

1 reference

https://api.crossref.org/works/10.1038%2FJID.2009.59

7 January 2021

Identifiers

DOI

10.1038/JID.2009.59

1 reference

Dimensions Publication ID

5 August 2017

0 references

1 reference