(Q39046334)

8 September 2017

Garp as a therapeutic target for modulation of T regulatory cell function (English)

1 reference

8 September 2017

Ethan M Shevach

1

1 reference

PubMed ID

28001437

8 September 2017

language of work or name

English

0 references

publication date

21 December 2016

1 reference

Expert Opinion on Therapeutic Targets

8 September 2017

1 reference

8 September 2017

21

1 reference

8 September 2017

2

1 reference

8 September 2017

191-200

1 reference

Regulatory T cells: mechanisms of differentiation and function

8 September 2017

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Regulatory T cells in autoimmmunity*.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

How regulatory T cells work

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Mechanisms of foxp3+ T regulatory cell-mediated suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

TGF-β activation and function in immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Latent TGF-β structure and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

New regulatory mechanisms of TGF-beta receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFbeta1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

CD28 disruption exacerbates inflammation in Tgf-beta1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-beta1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

GARP: a key receptor controlling FOXP3 in human regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Mesenchymal stromal cells express GARP/LRRC32 on their surface: effects on their biology and immunomodulatory capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

GARP regulates the bioavailability and activation of TGFβ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Release of active TGF-β1 from the latent TGF-β1/GARP complex on T regulatory cells is mediated by integrin β8

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

miR-142-3p is involved in CD25+ CD4 T cell proliferation by targeting the expression of glycoprotein A repetitions predominant

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

GARP is regulated by miRNAs and controls latent TGF-β1 production by human regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

GP96 is a GARP chaperone and controls regulatory T cell functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Soluble GARP has potent antiinflammatory and immunomodulatory impact on human CD4⁺ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

How Soluble GARP Enhances TGFβ Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

TGF-β in transplantation tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Role of beta7 integrins in intestinal lymphocyte homing and retention

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Integrin αEβ7: molecular features and functional significance in the immune system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Oral tolerance in the absence of naturally occurring Tregs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

The GARP/Latent TGF-β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

CD4⁺ T cells expressing latency-associated peptide and Foxp3 are an activated subgroup of regulatory T cells enriched in patients with colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Higher frequencies of GARP(+)CTLA-4(+)Foxp3(+) T regulatory cells and myeloid-derived suppressor cells in hepatocellular carcinoma patients are associated with impaired T-cell functionality

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Targeting immunosuppression by Tregs with monoclonal antibodies against GARP

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Selective targeting of TGF-β activation to treat fibroinflammatory airway disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Development and characterization of human monoclonal antibodies that neutralize multiple TGFβ isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

Phase 1 trial of transforming growth factor beta 2 in chronic progressive MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275568

10.1080/14728222.2017.1275568

21 January 2018

Identifiers

DOI

1 reference

8 September 2017

1 reference

PubMed ID

28001437