(Q39062404)

English

Overexpression of p62/SQSTM1 promotes the degradations of abnormally accumulated PrP mutants in cytoplasm and relieves the associated cytotoxicities via autophagy-lysosome-dependent way.

scientific article published on 17 November 2013

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scholarly article

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Europe PubMed Central

PubMed publication ID

8 September 2017

Overexpression of p62/SQSTM1 promotes the degradations of abnormally accumulated PrP mutants in cytoplasm and relieves the associated cytotoxicities via autophagy-lysosome-dependent way. (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

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10

object named as

Qi Shi

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8 September 2017

11

object named as

Xiao-Ping Dong

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8 September 2017

author name string

Yin Xu

1

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8 September 2017

Jin Zhang

2

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8 September 2017

Chan Tian

3

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8 September 2017

Ke Ren

4

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8 September 2017

Yu-E Yan

5

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8 September 2017

Ke Wang

6

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8 September 2017

Hui Wang

7

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8 September 2017

Cao Chen

8

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8 September 2017

Jing Wang

9

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8 September 2017

publication date

17 November 2013

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8 September 2017

Medical Microbiology and Immunology

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8 September 2017

203

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8 September 2017

2

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8 September 2017

73-84

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8 September 2017

https://scigraph.springernature.com/pub.10.1007/s00430-013-0316-z

0 references

Generating a prion with bacterially expressed recombinant prion protein

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

PrP octarepeats region determined the interaction with caveolin-1 and phosphorylation of caveolin-1 and Fyn.

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Therapeutic approaches for prion and Alzheimer's diseases

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Prion propagation and toxicity in vivo occur in two distinct mechanistic phases

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Protein disulfide isomerase regulates endoplasmic reticulum stress and the apoptotic process during prion infection and PrP mutant-induced cytotoxicity

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Heat shock protein 70 selectively mediates the degradation of cytosolic PrPs and restores the cytosolic PrP-induced cytotoxicity via a molecular interaction

1 reference

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21 January 2018

Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function

1 reference

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21 January 2018

p62/SQSTM1-dependent autophagy of Lewy body-like α-synuclein inclusions

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

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https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

1 reference

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21 January 2018

p62 at the crossroads of autophagy, apoptosis, and cancer

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21 January 2018

Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation.

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21 January 2018

p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases

1 reference

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21 January 2018

In vitro production of Mallory bodies and intracellular hyaline bodies: the central role of sequestosome 1/p62.

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Autophagy induction by trehalose counteracts cellular prion infection

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Guidelines for the use and interpretation of assays for monitoring autophagy

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Reticulon 3 attenuates the clearance of cytosolic prion aggregates via inhibiting autophagy

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

The roles of intracellular protein-degradation pathways in neurodegeneration

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Activation of the macroautophagic system in scrapie-infected experimental animals and human genetic prion diseases

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction

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21 January 2018

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Autophagy is a part of ultrastructural synaptic pathology in Creutzfeldt-Jakob disease: a brain biopsy study

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

A reporter cell system to monitor autophagy based on p62/SQSTM1.

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

p62 protects SH-SY5Y neuroblastoma cells against H2O2-induced injury through the PDK1/Akt pathway

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Stimulation of GSH synthesis to prevent oxidative stress-induced apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: activation of Nrf2 and JNK-p62/SQSTM1 pathways

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Delivery of single-chain antibodies (scFvs) directed against the 37/67 kDa laminin receptor into mice via recombinant adeno-associated viral vectors for prion disease gene therapy

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Increased ubiquitin-dependent degradation can replace the essential requirement for heat shock protein induction

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Heat Shock Proteins: Cell Protection through Protein Triage

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

4-hydroxytamoxifen leads to PrPSc clearance by conveying both PrPC and PrPSc to lysosomes independently of autophagy.

1 reference

https://api.crossref.org/works/10.1007%2FS00430-013-0316-Z

21 January 2018

Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein

1 reference

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The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24240628

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal autophagy in experimental scrapie

1 reference

https://pubmed.ncbi.nlm.nih.gov/24240628

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/24240628

12 December 2020

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inferred from PubMed ID database lookup

Comparison of the pathologic and pathogenic features in six different regions of postmortem brains of three patients with fatal familial insomnia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24240628

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00430-013-0316-Z

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

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