(Q39065919)

8 September 2017

title

Rho kinase inhibitors: a patent review (2014 - 2016). (English)

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8 September 2017

Olivier Defert

1

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8 September 2017

Sandro Boland

series ordinal

2

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8 September 2017

language of work or name

English

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publication date

3 January 2017

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Expert Opinion on Therapeutic Patents

8 September 2017

published in

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8 September 2017

volume

27

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8 September 2017

issue

4

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8 September 2017

page(s)

507-515

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ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

8 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Rho Kinases in Health and Disease: From Basic Science to Translational Research

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Rho kinase as a therapeutic target in cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Novel investigational therapies for treating pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: Bench to bedside research

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

The future is today: emerging drugs for the treatment of erectile dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Novel Insights into the Roles of Rho Kinase in Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Novel ocular antihypertensive compounds in clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Ripasudil: first global approval

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Double-masked, randomized, dose-response study of AR-13324 versus latanoprost in patients with elevated intraocular pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Ocular hypotensive safety and systemic absorption of AR-13324 ophthalmic solution in normal volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

AMA0076, a novel, locally acting Rho kinase inhibitor, potently lowers intraocular pressure in New Zealand white rabbits with minimal hyperemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Rho kinase inhibitors: a patent review (2012 - 2013).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Kinase profiling in early stage drug discovery: sorting things out.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Selective ROCK2 inhibition in focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Novel Oral Therapies for Psoriasis and Psoriatic Arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

3-[2-(Aminomethyl)-5-[(pyridin-4-yl)carbamoyl]phenyl] benzoates as soft ROCK inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

The effect of AMA0428, a novel and potent ROCK inhibitor, in a model of neovascular age-related macular degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Design, synthesis, and biological evaluation of novel, highly active soft ROCK inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Design and synthesis of Rho kinase inhibitors (I).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Design and synthesis of Rho kinase inhibitors (II).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Design and synthesis of rho kinase inhibitors (III).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Novel glucocorticoid antedrugs possessing a 17beta-(gamma-lactone) ring.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

One-year clinical evaluation of 0.4% ripasudil (K-115) in patients with open-angle glaucoma and ocular hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1272579

10.1080/13543776.2017.1272579

21 January 2018

Identifiers

DOI

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8 September 2017

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