(Q34601386)

3 August 2017

title

Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism (English)

1 reference

3 August 2017

Michael L Dustin

19

0 references

Bruce R Blazar

20

object named as

Bruce R Blazar

1 reference

3 August 2017

18

Keli L Hippen

1 reference

3 August 2017

Alexandra Zanin-Zhorov

1

object named as

Alexandra Zanin-Zhorov

1 reference

3 August 2017

Jonathan M Weiss

2

1 reference

3 August 2017

Melanie S Nyuydzefe

3

1 reference

3 August 2017

Wei Chen

4

1 reference

3 August 2017

Jose U Scher

5

1 reference

3 August 2017

Rigen Mo

6

1 reference

3 August 2017

David Depoil

7

1 reference

3 August 2017

Nishta Rao

8

1 reference

3 August 2017

Ben Liu

9

1 reference

3 August 2017

Jianlu Wei

10

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3 August 2017

Sarah Lucas

11

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3 August 2017

Matthew Koslow

12

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3 August 2017

Maria Roche

13

1 reference

3 August 2017

Olivier Schueller

14

1 reference

3 August 2017

Sara Weiss

15

1 reference

3 August 2017

Masha V Poyurovsky

16

1 reference

3 August 2017

James Tonra

17

1 reference

3 August 2017

Chuan-ju Liu

21

1 reference

3 August 2017

Samuel D Waksal

22

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3 August 2017

language of work or name

English

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publication date

10 November 2014

1 reference

Proceedings of the National Academy of Sciences of the United States of America

3 August 2017

published in

1 reference

3 August 2017

volume

111

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3 August 2017

issue

47

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3 August 2017

page(s)

16814-16819

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Selective ROCK2 inhibition in focal cerebral ischemia

3 August 2017

cites work

1 reference

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7 July 2018

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Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis

7 July 2018

1 reference

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Cytokine secretion by CD4+ T cells at the immunological synapse requires Cdc42-dependent local actin remodeling but not microtubule organizing center polarity

7 July 2018

1 reference

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Optimization of current and future therapy for autoimmune diseases

7 July 2018

1 reference

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Targeting interleukin-21 in inflammatory diseases

7 July 2018

1 reference

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Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice

7 July 2018

1 reference

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Protein kinase C-theta mediates negative feedback on regulatory T cell function

7 July 2018

1 reference

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IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?

7 July 2018

1 reference

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Th17 cytokines and arthritis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

Functional anatomy of T cell activation and synapse formation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

Rho family GTPases and their regulators in lymphocytes.

7 July 2018

1 reference

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Plasticity of CD4+ T cell lineage differentiation.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

Human Th17 cells in infection and autoimmunity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

Critical regulation of early Th17 cell differentiation by interleukin-1 signaling

7 July 2018

1 reference

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7 July 2018

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Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

TH17 cells in development: an updated view of their molecular identity and genetic programming

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

Applications for ROCK kinase inhibition

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

Transcriptional regulation of Th17 cell differentiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

Rocks: multifunctional kinases in cell behaviour

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

Rac1 mediates STAT3 activation by autocrine IL-6

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

Regulation of STAT3 by direct binding to the Rac1 GTPase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4250132

Antiinflammatory effect of Rho kinase blockade via inhibition of NF-kappaB activation in rheumatoid arthritis

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1414189111

A role of STAT3 in Rho GTPase-regulated cell migration and proliferation

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1414189111

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1414189111

Development of anti-TNF therapy for rheumatoid arthritis

21 January 2018

1 reference

12 December 2020

The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4

1 reference

12 December 2020

The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis

1 reference

12 December 2020

How does the immune system distinguish self from nonself?

1 reference

12 December 2020

Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1414189111

1 reference

3 August 2017

0 references

1 reference

3 August 2017

1 reference