(Q39070506)

8 September 2017

title

Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells (English)

1 reference

8 September 2017

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28060562%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Osamu Takeuchi

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28060562%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Osamu Takeuchi

series ordinal

2

1 reference

8 September 2017

publication date

6 January 2017

1 reference

International Reviews of Immunology

8 September 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28060562%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28060562%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28060562%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

page(s)

57-73

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28060562%20AND%20SRC:MED&resulttype=core&format=json

Pattern recognition receptors and inflammation

9 June 2020

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Toll-like receptor signalling

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The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

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Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

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The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

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TLR11 activation of dendritic cells by a protozoan profilin-like protein.

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Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii

21 January 2018

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Pathogen recognition and innate immunity

21 January 2018

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Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

21 January 2018

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Cutting edge: TLR13 is a receptor for bacterial RNA

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TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification

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A novel Toll-like receptor that recognizes vesicular stomatitis virus

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Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2.

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Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein

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Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4.

21 January 2018

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The extra domain A of fibronectin activates Toll-like receptor 4.

21 January 2018

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Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain.

21 January 2018

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The TLR4 antagonist Eritoran protects mice from lethal influenza infection

21 January 2018

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Randomized, double-blind, placebo-controlled, dose-escalating phase I, healthy subjects study of intravenous OPN-305, a humanized anti-TLR2 antibody

21 January 2018

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IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

21 January 2018

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Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

21 January 2018

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Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

21 January 2018

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Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

21 January 2018

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Transcriptional control of inflammatory responses

21 January 2018

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Chromatin contributions to the regulation of innate immunity

21 January 2018

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Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Chromatin Remodeling and Transcriptional Control in Innate Immunity: Emergence of Akirin2 as a Novel Player

21 January 2018

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Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling

21 January 2018

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Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

21 January 2018

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A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

21 January 2018

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

21 January 2018

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DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

21 January 2018

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RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

21 January 2018

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The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway

21 January 2018

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DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

21 January 2018

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Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

21 January 2018

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The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

21 January 2018

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Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

21 January 2018

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Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects

21 January 2018

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

21 January 2018

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Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists

21 January 2018

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Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells

21 January 2018

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Nucleotide-binding oligomerization domain protein 2-deficient mice control infection with Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Signalling through C-type lectin receptors: shaping immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

The SYK tyrosine kinase: a crucial player in diverse biological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

The adaptor molecule CARD9 is essential for tuberculosis control

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

TLR3 deficiency in patients with herpes simplex encephalitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Inflammation and cancer: back to Virchow?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Tumour-educated macrophages promote tumour progression and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Cancer-related inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Immunity, Inflammation, and Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Tumor-associated macrophages and survival in classic Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Macrophage diversity enhances tumor progression and metastasis

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Cancer relapse under chemotherapy: why TLR2/4 receptor agonists can help

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Programming the magnitude and persistence of antibody responses with innate immunity

21 January 2018

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The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Monophosphoryl Lipid A (MPL) as an Adjuvant for Anti-Cancer Vaccines: Clinical Results

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Activation of Toll-like receptor 5 on breast cancer cells by flagellin suppresses cell proliferation and tumor growth

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models

21 January 2018

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Therapeutic potential of Toll-like receptor 9 activation

21 January 2018

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The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation.

21 January 2018

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https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

The IKK NF-kappa B system: a treasure trove for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

HMGB1 and RAGE in inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Impact of Toll-like receptor 4 polymorphisms on risk of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Human lung cancer cells express functionally active Toll-like receptor 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

MicroRNAs: target recognition and regulatory functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

microRNAs: tiny regulators with great potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Role of microRNAs in lymphoid biology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Causes and consequences of microRNA dysregulation in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

An exploratory study of systemic administration of the toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

A well-tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injections

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Activation of Toll-like receptor 2 by a novel preparation of cell wall skeleton from Mycobacterium bovis BCG Tokyo (SMP-105) sufficiently enhances immune responses against tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Epithelioid granulomas, pattern recognition receptors, and phenotypes of Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Toll-like receptor 7 rs179008/Gln11Leu gene variants in chronic hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

A Toll-like receptor 7 single nucleotide polymorphism protects from advanced inflammation and fibrosis in male patients with chronic HCV-infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Toll-like receptor 8 and 9 polymorphisms in Crimean-Congo hemorrhagic fever.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

The C allele of rs5743836 polymorphism in the human TLR9 promoter links IL-6 and TLR9 up-regulation and confers increased B-cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Evaluation of Toll-like receptors 3 (c.1377C/T) and 9 (G2848A) gene polymorphisms in cervical cancer susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Synergistic enhancement of Toll-like receptor responses by NOD1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

A Common Polymorphism in TLR3 Confers Natural Resistance to HIV-1 Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

TLR1 and TLR6 Polymorphisms Are Associated with Susceptibility to Invasive Aspergillosis after Allogeneic Stem Cell Transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

Toll-like Receptor 4 Polymorphisms and Atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830185.2016.1261318

10.1080/08830185.2016.1261318

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28060562%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference