(Q39077441)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24135036%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

Mutations in MAP3K1 tilt the balance from SOX9/FGF9 to WNT/β-catenin signaling (English)

1 reference

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28 February 2020

4

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28 February 2020

author name string

Johnny Loke

1

1 reference

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28 February 2020

Alexander Pearlman

2

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28 February 2020

Orietta Radi

3

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28 February 2020

Ursula Giussani

5

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28 February 2020

Rosanna Pallotta

6

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28 February 2020

Giovanna Camerino

7

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28 February 2020

Harry Ostrer

8

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28 February 2020

language of work or name

1 reference

16 October 2013

1 reference

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28 February 2020

published in

Human Molecular Genetics

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28 February 2020

volume

23

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28 February 2020

issue

4

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28 February 2020

page(s)

1073-1083

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Mixed signals: development of the testis

28 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

The makings of maleness: towards an integrated view of male sexual development

21 January 2018

1 reference

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Mammalian sex determination—insights from humans and mice

21 January 2018

1 reference

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A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

21 January 2018

1 reference

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R-spondin1 is essential in sex determination, skin differentiation and malignancy.

21 January 2018

1 reference

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Male development of chromosomally female mice transgenic for Sry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Sox9 induces testis development in XX transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Genetic evidence equating SRY and the testis-determining factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.

21 January 2018

1 reference

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Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Interactions between Sox9 and beta-catenin control chondrocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Rapidly screening variants of uncertain significance in the MAP3K1 gene for phenotypic effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Identification of the Axin and Frat binding region of glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Characterisation of urogenital ridge gene expression in the human embryonal carcinoma cell line NT2/D1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Wnt signaling in ovarian development inhibits Sf1 activation of Sox9 via the Tesco enhancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Mitogen-activated protein kinases and Wnt/beta-catenin signaling: Molecular conversations among signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPK activation and mRNA stabilization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

The transcriptional activity of Sox9 in chondrocytes is regulated by RhoA signaling and actin polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT502

21 January 2018

Identifiers

DOI

10.1093/HMG/DDT502

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24135036%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference