(Q51116639)

30 March 2018

title

Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPK activation and mRNA stabilization. (English)

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30 March 2018

author

Timothy E. Hardingham

series ordinal

2

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30 March 2018

Simon R Tew

object named as

Simon R Tew

series ordinal

1

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language of work or name

English

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publication date

18 October 2006

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30 March 2018

Journal of Biological Chemistry

number of pages

9

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based on heuristic

inferred from page(s)

published in

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30 March 2018

volume

281

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30 March 2018

issue

51

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30 March 2018

page(s)

39471-39479

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30 March 2018

SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene

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Regulation of type-II collagen gene expression during human chondrocyte de-differentiation and recovery of chondrocyte-specific phenotype in culture involves Sry-type high-mobility-group box (SOX) transcription factors

21 January 2018

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Tissue engineering: chondrocytes and cartilage

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Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes.

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Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway

21 January 2018

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Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha

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Position effects due to chromosome breakpoints that map approximately 900 Kb upstream and approximately 1.3 Mb downstream of SOX9 in two patients with campomelic dysplasia

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Activation and signaling of the p38 MAP kinase pathway

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Superinduction of IL-6 by cycloheximide is associated with mRNA stabilization and sustained activation of p38 map kinase and NF-kappaB in cultured caco-2 cells.

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Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes

21 January 2018

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Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition

21 January 2018

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Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes

21 January 2018

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p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation

21 January 2018

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RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation.

21 January 2018

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Rho and Rac take center stage

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RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis.

21 January 2018

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21 January 2018

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Re-expression of differentiated proteoglycan phenotype by dedifferentiated human chondrocytes during culture in alginate beads

21 January 2018

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Cartilage oligomeric matrix protein (COMP) and collagen IX are sensitive markers for the differentiation state of articular primary chondrocytes

21 January 2018

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Control of human articular chondrocyte differentiation by reduced oxygen tension

21 January 2018

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Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2

21 January 2018

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Superinduction of COX-2 mRNA by cycloheximide and interleukin-1beta involves increased transcription and correlates with increased NF-kappaB and JNK activation

21 January 2018

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AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A).

21 January 2018

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21 January 2018

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The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter.

21 January 2018

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Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells

21 January 2018

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UV stimulation of nucleophosmin/B23 expression is an immediate-early gene response induced by damaged DNA

21 January 2018

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Regulation of connective tissue growth factor (CTGF/CCN2) gene transcription and mRNA stability in smooth muscle cells. Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics

21 January 2018

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Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways

21 January 2018

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SOX9 expression does not correlate with type II collagen expression in adult articular chondrocytes.

21 January 2018

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RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner.

21 January 2018

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Differentiation regulates interleukin-1beta-induced cyclo-oxygenase-2 in human articular chondrocytes: role of p38 mitogen-activated protein kinase

21 January 2018

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Coordinate down-regulation of cartilage matrix gene expression in Bcl-2 deficient chondrocytes is associated with decreased SOX9 expression and decreased mRNA stability

21 January 2018

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p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts

21 January 2018

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AU-rich elements: characterization and importance in mRNA degradation

21 January 2018

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Immunosuppressant rapamycin inhibits protein kinase C alpha and p38 mitogen-activated protein kinase leading to the inhibition of chondrogenesis.

21 January 2018

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Requirement for RAR-mediated gene repression in skeletal progenitor differentiation

21 January 2018

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Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation

21 January 2018

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Interactions between Sox9 and beta-catenin control chondrocyte differentiation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M604322200

1 reference

30 March 2018

1 reference

30 March 2018