(Q39113045)

English

Triptolide, a Chinese herbal extract, enhances drug sensitivity of resistant myeloid leukemia cell lines through downregulation of HIF-1α and Nrf2.

scientific article published on August 2013

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scholarly article

1 reference

Europe PubMed Central

9 September 2017

Triptolide, a Chinese herbal extract, enhances drug sensitivity of resistant myeloid leukemia cell lines through downregulation of HIF-1α and Nrf2. (English)

1 reference

Europe PubMed Central

9 September 2017

1 reference

based on heuristic

inferred from title

myeloid leukemia

1 reference

based on heuristic

inferred from title

author name string

Feili Chen

1

1 reference

Europe PubMed Central

9 September 2017

Yuejian Liu

2

1 reference

Europe PubMed Central

9 September 2017

Shiyun Wang

3

1 reference

Europe PubMed Central

9 September 2017

Xutao Guo

4

1 reference

Europe PubMed Central

9 September 2017

Pengcheng Shi

5

1 reference

Europe PubMed Central

9 September 2017

Weiguang Wang

6

1 reference

Europe PubMed Central

9 September 2017

Bing Xu

7

1 reference

Europe PubMed Central

9 September 2017

publication date

1 August 2013

1 reference

Europe PubMed Central

9 September 2017

Pharmacogenomics

1 reference

Europe PubMed Central

9 September 2017

14

1 reference

Europe PubMed Central

9 September 2017

11

1 reference

Europe PubMed Central

9 September 2017

1305-1317

1 reference

Europe PubMed Central

9 September 2017

The role of MDR-related proteins in the prognosis of adult acute myeloid leukaemia (AML) with normal karyotype.

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Merging traditional Chinese medicine with modern drug discovery technologies to find novel drugs and functional foods

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Triptolide and its expanding multiple pharmacological functions

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-κB activity and miR-16-1*.

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Triptolide cooperates with chemotherapy to induce apoptosis in acute myeloid leukemia cells.

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Triptolide triggers the apoptosis of pancreatic cancer cells via the downregulation of Decoy receptor 3 expression

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamsters

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Triptolide simultaneously induces reactive oxygen species, inhibits NF-kappaB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii.

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Triptolide sensitizes TRAIL-induced apoptosis in prostate cancer cells via p53-mediated DR5 up-regulation

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Triptolide cooperates with Cisplatin to induce apoptosis in gemcitabine-resistant pancreatic cancer.

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Triptolide enhances the sensitivity of multiple myeloma cells to dexamethasone via microRNAs

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

NRF2 and cancer: the good, the bad and the importance of context.

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance.

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms.

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

The role of hypoxia-inducible factors in tumorigenesis.

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Hypoxia--a key regulatory factor in tumour growth

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Hypoxia-inducible factor-1α protein expression is associated with poor survival in normal karyotype adult acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Philadelphia chromosome-positive acute lymphoblastic leukemia: current treatment and future perspectives

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs.

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-dependent apoptosis and down-regulation of HIF-1α.

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part I.

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part II.

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprograming

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Nuclear expression of hypoxia-inducible factor 1alpha protein is heterogeneous in human malignant cells under normoxic conditions

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Targeting HIF1α eliminates cancer stem cells in hematological malignancies.

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast.

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

High basal nuclear levels of Nrf2 in acute myeloid leukemia reduces sensitivity to proteasome inhibitors

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Hemin reduces cellular sensitivity to imatinib and anthracyclins via Nrf2.

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Role of Nrf2 in protection against triptolide-induced toxicity in rat kidney cells

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

The cytoprotective role of the Keap1-Nrf2 pathway

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging

1 reference

https://api.crossref.org/works/10.2217%2FPGS.13.122

21 January 2018

Identifiers

10.2217/PGS.13.122

1 reference

Europe PubMed Central

9 September 2017

1 reference

Europe PubMed Central

9 September 2017

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