(Q39143046)

9 September 2017

Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP. (English)

1 reference

9 September 2017

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Robert J Ardecky

1

1 reference

9 September 2017

Kate Welsh

2

1 reference

9 September 2017

Darren Finlay

3

1 reference

9 September 2017

Pooi San Lee

4

1 reference

9 September 2017

Marcos González-López

5

1 reference

9 September 2017

Santhi Reddy Ganji

6

1 reference

9 September 2017

Palaniyandi Ravanan

7

1 reference

9 September 2017

Peter D Mace

8

1 reference

9 September 2017

Stefan J Riedl

9

1 reference

9 September 2017

Kristiina Vuori

10

1 reference

9 September 2017

John C Reed

11

1 reference

9 September 2017

Nicholas D P Cosford

12

1 reference

9 September 2017

language of work or name

English

0 references

publication date

14 May 2013

1 reference

Bioorganic & Medicinal Chemistry Letters

9 September 2017

1 reference

9 September 2017

23

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9 September 2017

14

1 reference

9 September 2017

4253-4257

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Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

Targeting IAP proteins for therapeutic intervention in cancer

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

Cyclopeptide Smac mimetics as antagonists of IAP proteins

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

Small-molecule pan-IAP antagonists: a patent review

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

IAP antagonists: promising candidates for cancer therapy

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

Human caspases: activation, specificity, and regulation

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

Design of small-molecule peptidic and nonpeptidic Smac mimetics

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

The mechanism of peptide-binding specificity of IAP BIR domains

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

Targeting XIAP for the treatment of malignancy

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

Mechanisms of cancer drug resistance

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

Structural basis for the inhibition of caspase-3 by XIAP

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

10 September 2017

The Hallmarks of Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3772719

Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23743278

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Characterization of a heterodimeric Smac-based peptide that features sequences specific to both the BIR2 and BIR3 domains of the X-linked inhibitor of apoptosis protein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23743278

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BMCL.2013.04.096

1 reference

release_dpjv5bnqird4fooma3kx25hjti

9 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/dpjv5bnqird4fooma3kx25hjti

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

9 September 2017

PubMed publication ID

23743278

1 reference