(Q39143876)

9 September 2017

title

CHO cell line specific prediction and control of recombinant monoclonal antibody N-glycosylation (English)

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9 September 2017

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Rhian K Grainger

1

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9 September 2017

David C James

series ordinal

2

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9 September 2017

language of work or name

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6 June 2013

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Biotechnology and Bioengineering

9 September 2017

published in

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9 September 2017

volume

110

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9 September 2017

issue

11

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9 September 2017

page(s)

2970-2983

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Improvement of CHO cell culture medium formulation: simultaneous substitution of glucose and glutamine

9 September 2017

cites work

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Decoupling cell growth and product formation in Chinese hamster ovary cells through metabolic control

21 January 2018

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Strategies for fed-batch cultivation of t-PA producing CHO cells: substitution of glucose and glutamine and rational design of culture medium

21 January 2018

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Considerations on the lactate consumption by CHO cells in the presence of galactose

21 January 2018

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The impact of glycosylation on the biological function and structure of human immunoglobulins.

21 January 2018

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Metabolic control of recombinant protein N-glycan processing in NS0 and CHO cells

21 January 2018

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21 January 2018

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Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars

21 January 2018

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Studies on the metal binding sites in the catalytic domain of beta1,4-galactosyltransferase

21 January 2018

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Synergizing metabolic flux analysis and nucleotide sugar metabolism to understand the control of glycosylation of recombinant protein in CHO cells

21 January 2018

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Effects of elevated ammonium on glycosylation gene expression in CHO cells

21 January 2018

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Amino acid and manganese supplementation modulates the glycosylation state of erythropoietin in a CHO culture system.

21 January 2018

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Functional heterogeneity and heritability in CHO cell populations

21 January 2018

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Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

21 January 2018

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A comparison of the fine saccharide-binding specificity of Dioclea grandiflora lectin and concanavalin A.

21 January 2018

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Humanization of yeast to produce complex terminally sialylated glycoproteins

21 January 2018

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Metabolic control of recombinant monoclonal antibody N-glycosylation in GS-NS0 cells

21 January 2018

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Control of recombinant monoclonal antibody effector functions by Fc N-glycan remodeling in vitro

21 January 2018

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Systems analysis of N-glycan processing in mammalian cells

21 January 2018

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Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

21 January 2018

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Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action

21 January 2018

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Characterization of the glycosylation occupancy and the active site in the follow-on protein therapeutic: TNK-tissue plasminogen activator

21 January 2018

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A dynamic mathematical model for monoclonal antibody N-linked glycosylation and nucleotide sugar donor transport within a maturing Golgi apparatus

21 January 2018

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Sialylation enhancement of CTLA4-Ig fusion protein in Chinese hamster ovary cells by dexamethasone

21 January 2018

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Superior in vivo efficacy of afucosylated trastuzumab in the treatment of HER2-amplified breast cancer

21 January 2018

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Assembly of asparagine-linked oligosaccharides

21 January 2018

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A predictive high-throughput scale-down model of monoclonal antibody production in CHO cells.

21 January 2018

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High-throughput lectin microarray-based analysis of live cell surface glycosylation

21 January 2018

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Glycosylation of an immunoglobulin produced from a murine hybridoma cell line: the effect of culture mode and the anti-apoptotic gene, bcl-2.

21 January 2018

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Differences in the binding affinities of dimeric concanavalin A (including acetyl and succinyl derivatives) and tetrameric concanavalin A with large oligomannose-type glycopeptides

21 January 2018

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Bioprocess optimization using design-of-experiments methodology

21 January 2018

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Effects of buffering conditions and culture pH on production rates and glycosylation of clinical phase I anti-melanoma mouse IgG3 monoclonal antibody R24.

21 January 2018

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Defucosylated chimeric anti-CC chemokine receptor 4 IgG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T-cell leukemia and lymphoma

21 January 2018

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Effects of cell culture conditions on antibody N-linked glycosylation--what affects high mannose 5 glycoform

21 January 2018

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Lectin-resistant CHO glycosylation mutants

21 January 2018

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In vitro galactosylation of a 110-kDa glycoprotein by an endogenous cell surface galactosyltransferase correlates with the invasiveness of adrenal carcinoma cells

21 January 2018

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Cell surface glycoproteins undergo postbiosynthetic modification of their N-glycans by stepwise demannosylation.

21 January 2018

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Structure and catalytic cycle of beta-1,4-galactosyltransferase

21 January 2018

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Lectin-resistant CHO cells: selection of four new pea lectin-resistant phenotypes.

21 January 2018

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Two Chinese hamster ovary glycosylation mutants affected in the conversion of GDP-mannose to GDP-fucose

21 January 2018

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Acceptable changes in quality attributes of glycosylated biopharmaceuticals

21 January 2018

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A comparison of different methods to determine the end of exponential growth in CHO cell cultures for optimization of scale-up.

21 January 2018

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Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

21 January 2018

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Fed-batch operation of an industrial cell culture process in shaken microwells

21 January 2018

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Effects of uridine on the growth and differentiation of HL-60 leukemia cells

21 January 2018

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Selection of specific wheat germ agglutinin-resistant (WgaR) phenotypes from Chinese hamster ovary cell populations containing numerous lecR genotypes

21 January 2018

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Complementation between mutants of CHO cells resistant to a variety of plant lectins

21 January 2018

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Selection and characterization of eight phenotypically distinct lines of lectin-resistant chinese hamster ovary cells

21 January 2018

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Chinese hamster ovary cells selected for resistance to the cytotoxicity of phytohemagglutinin are deficient in a UDP-N-acetylglucosamine--glycoprotein N-acetylglucosaminyltransferase activity

21 January 2018

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The effect of osmolarity on metabolism and morphology in adhesion and suspension chinese hamster ovary cells producing tissue plasminogen activator

21 January 2018

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Lectin microarrays identify cell-specific and functionally significant cell surface glycan markers.

21 January 2018

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A novel strategy for mammalian cell surface glycome profiling using lectin microarray.

21 January 2018

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N-linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG.

21 January 2018

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Phase 1 study of anti-epidermal growth factor receptor monoclonal antibody in patients with solid tumors

21 January 2018

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In vitro galactosylation of human IgG at 1 kg scale using recombinant galactosyltransferase

21 January 2018

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An investigation of intracellular glycosylation activities in CHO cells: effects of nucleotide sugar precursor feeding

21 January 2018

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Rapid comparison of a candidate biosimilar to an innovator monoclonal antibody with advanced liquid chromatography and mass spectrometry technologies

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIT.24959

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9 September 2017

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