(Q39148056)

English

Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway.

scientific article published on 23 May 2013

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scholarly article

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1 March 2020

Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway (English)

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1 March 2020

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1 March 2020

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A Hyrskyluoto

1

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1 March 2020

I Pulli

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1 March 2020

K Törnqvist

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1 March 2020

L Korhonen

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1 March 2020

D Lindholm

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23 May 2013

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1 March 2020

Cell Death and Disease

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1 March 2020

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1 March 2020

e646

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1 March 2020

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1 May 2013

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The sigma-1 receptor: roles in neuronal plasticity and disease

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Compromising σ-1 receptors at the endoplasmic reticulum render cytotoxicity to physiologically relevant concentrations of dopamine in a nuclear factor-κB/Bcl-2-dependent mechanism: potential relevance to Parkinson's disease

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Sigma receptor agonist 2-(4-morpholinethyl)1 phenylcyclohexanecarboxylate (Pre084) increases GDNF and BiP expression and promotes neuroprotection after root avulsion injury

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Downregulation of NF-kappaB signaling by mutant huntingtin proteins induces oxidative stress and cell death

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Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB

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NF-kappaB-dependent regulation of brain-derived neurotrophic factor in hippocampal neurons by X-linked inhibitor of apoptosis protein

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Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand

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Selective sigma receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons.

1 reference

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Calcium-sensitive photoproteins.

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Low density of sigma1 receptors in early Alzheimer's disease

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Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity.

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21 August 2018

Function of sigma1 receptors in Parkinson's disease

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Hippocalcin protects against caspase-12-induced and age-dependent neuronal degeneration

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Transfected aequorin in the measurement of cytosolic Ca2+ concentration ([Ca2+]c). A critical evaluation.

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21 August 2018

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10.1038/CDDIS.2013.170

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1 March 2020

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1 March 2020

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1 March 2020

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