(Q39148424)

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An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins.

scientific article published on October 2013

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23700228%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23700228%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

hepatocellular carcinoma

1 reference

based on heuristic

inferred from title

Kodappully Sivaraman Siveen

8

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23700228%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Peramaiyan Rajendran

3

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1 March 2020

11

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1 March 2020

13

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1 March 2020

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Aruljothi Subramaniam

1

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1 March 2020

Ser Yue Loo

2

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1 March 2020

Kanjoormana A Manu

4

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1 March 2020

Ekambaram Perumal

5

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1 March 2020

Feng Li

6

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1 March 2020

Muthu K Shanmugam

7

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1 March 2020

Joo-In Park

9

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1 March 2020

Kwang Seok Ahn

10

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1 March 2020

Alan P Kumar

12

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1 March 2020

publication date

1 October 2013

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1 March 2020

1 reference

Europe PubMed Central

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1 March 2020

18

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1 March 2020

10

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1 March 2020

1175-1187

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23700228%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Hepatocellular carcinoma: A global view.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Cancer statistics, 2012

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

New therapies for hepatocellular carcinoma.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Is TRAIL the holy grail of cancer therapy?

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

TRAIL receptor signaling and therapeutics.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Combining naturally occurring polyphenols with TNF-related apoptosis-inducing ligand: a promising approach to kill resistant cancer cells?

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Butein sensitizes human hepatoma cells to TRAIL-induced apoptosis via extracellular signal-regulated kinase/Sp1-dependent DR5 upregulation and NF-kappaB inactivation

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

TRAIL-R4 promotes tumor growth and resistance to apoptosis in cervical carcinoma HeLa cells through AKT

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Is there a role for nuclear factor kappaB in tumor necrosis factor-related apoptosis-inducing ligand resistance?

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

TRADD is critical for resistance to TRAIL-induced cell death through NF-κB activation

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Dovitinib sensitizes hepatocellular carcinoma cells to TRAIL and tigatuzumab, a novel anti-DR5 antibody, through SHP-1-dependent inhibition of STAT3.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Chemopreventive effects of emodin and cassiamin B in mouse skin carcinogenesis

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Targeting HER2: recent developments and future directions for breast cancer patients

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Apoptosis-inducing activity of new pyrazole emodin derivatives in human hepatocellular carcinoma HepG2 cells

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Involvement of matrix metalloproteinases on the inhibition of cells invasion and migration by emodin in human neuroblastoma SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Emodin-induced apoptosis through p53-dependent pathway in human hepatoma cells

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

The replacement of ATP by the competitive inhibitor emodin induces conformational modifications in the catalytic site of protein kinase CK2

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Inhibitory effect of emodin on tumor invasion through suppression of activator protein-1 and nuclear factor-kappaB.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Emodin and DHA potently increase arsenic trioxide interferon-alpha-induced cell death of HTLV-I-transformed cells by generation of reactive oxygen species and inhibition of Akt and AP-1

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Mechanisms of resistance to TRAIL-induced apoptosis in cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Differential responsiveness of human hepatoma cells versus normal hepatocytes to TRAIL in combination with either histone deacetylase inhibitors or conventional cytostatics

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

The synthetic cannabinoid WIN 55,212-2 sensitizes hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating p8/CCAAT/enhancer binding protein homologous protein (CHOP)/death rec

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Inhibition of casein kinase 2 enhances the death ligand- and natural kiler cell-induced hepatocellular carcinoma cell death

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

TRAIL: a sword for killing tumors

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Inhibition of death receptor signals by cellular FLIP

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Rosiglitazone promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

TRAILing death in cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Potential pharmacological control of the NF-κB pathway

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5).

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

Guggulsterone sensitizes hepatoma cells to TRAIL-induced apoptosis through the induction of CHOP-dependent DR5: involvement of ROS-dependent ER-stress

1 reference

https://api.crossref.org/works/10.1007%2FS10495-013-0851-5

21 January 2018

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