(Q37302737)

19 August 2017

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title

The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway (English)

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19 August 2017

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S Wang

1

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19 August 2017

language of work or name

English

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publication date

1 October 2008

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19 August 2017

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19 August 2017

volume

27

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19 August 2017

issue

48

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19 August 2017

page(s)

6207-6215

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https://scigraph.springernature.com/pub.10.1038/onc.2008.298

19 August 2017

exact match

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cites work

Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

To kill a tumor cell: the potential of proapoptotic receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Safety and antitumor activity of recombinant soluble Apo2 ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

The role of tumor stroma in the interaction between tumor and immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

TRAIL-R as a negative regulator of innate immune cell responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

DR5 knockout mice are compromised in radiation-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Clearing the TRAIL for Cancer Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

How melanoma cells evade trail-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

A phase 1 study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Enhancement of death receptor 4 mediated apoptosis and cytotoxicity in renal cell carcinoma cells by subtoxic concentrations of doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

The caspase-8 modulator c-FLIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

TRAIL inactivates the mitotic checkpoint and potentiates death induced by microtubule-targeting agents in human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Mcl-1: a gateway to TRAIL sensitization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

DR5 receptor mediates anoikis in human colorectal carcinoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

The involvement of TNF-alpha-related apoptosis-inducing ligand in the enhanced cytotoxicity of IFN-beta-stimulated human dendritic cells to tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Soluble TRAIL concentrations are raised in patients with systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

The potential of the tumor microenvironment to influence Apo2L/TRAIL induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

AKT/PKB signaling: navigating downstream

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

A novel receptor for Apo2L/TRAIL contains a truncated death domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Defining characteristics of Types I and II apoptotic cells in response to TRAIL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

An antagonist decoy receptor and a death domain-containing receptor for TRAIL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

The receptor for the cytotoxic ligand TRAIL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Sensitization of mesothelioma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by heat stress via the inhibition of the 3-phosphoinositide-dependent kinase 1/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Potential methods to circumvent blocks in apoptosis in lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Sensitization of prostate carcinoma cells to Apo2L/TRAIL by a Bcl-2 family protein inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Canonical nuclear factor kappaB pathway inhibition blocks myeloma cell growth and induces apoptosis in strong synergy with TRAIL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Gefitinib reverses TRAIL resistance in human bladder cancer cell lines via inhibition of AKT-mediated X-linked inhibitor of apoptosis protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Nature's TRAIL--on a path to cancer immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

TRAIL and apoptosis induction by TNF-family death receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Identification and characterization of a new member of the TNF family that induces apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Functional expression of TRAIL receptors TRAIL-R1 and TRAIL-R2 in esophageal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

The von hippel-lindau tumor suppressor protein: an update

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Nuclear factor-kappaB maintains TRAIL resistance in human pancreatic cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

p53 status and the efficacy of cancer therapy in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: enhanced effects in vitro and dose-dependent growth delay in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.298

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.298

1 reference

Dimensions Publication ID

19 August 2017

1046312268

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1 reference