(Q40094198)

English

Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization.

scientific article published on 13 August 2007

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3 January 2020

Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization (English)

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3 January 2020

Scott H Kaufmann

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3 January 2020

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Alex A Adjei

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3 January 2020

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Shaji K Kumar

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3 January 2020

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Xue Wei Meng

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3 January 2020

Sun-Hee Lee

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3 January 2020

Haiming Dai

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3 January 2020

David Loegering

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3 January 2020

Chunrong Yu

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3 January 2020

Karen Flatten

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3 January 2020

Paula Schneider

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3 January 2020

Nga T Dai

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3 January 2020

B Douglas Smith

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3 January 2020

Judith E Karp

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3 January 2020

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13 August 2007

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3 January 2020

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3 January 2020

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3 January 2020

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3 January 2020

29831-29846

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3 January 2020

Nature's TRAIL--on a path to cancer immunotherapy

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Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity.

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Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL.

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21 January 2018

Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development

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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis

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Targeting death and decoy receptors of the tumour-necrosis factor superfamily

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TRAIL and apoptosis induction by TNF-family death receptors.

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Death receptor-induced cell killing

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Mammalian caspases: structure, activation, substrates, and functions during apoptosis

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Two CD95 (APO-1/Fas) signaling pathways

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21 January 2018

Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein

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21 January 2018

Mammalian mitochondrial IAP binding proteins

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21 January 2018

The differential sensitivity of Bc1-2-overexpressing human breast tumor cells to TRAIL or doxorubicin-induced apoptosis is dependent on Bc1-2 protein levels.

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Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance

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Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach.

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21 January 2018

Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression.

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21 January 2018

Mechanisms of resistance to TRAIL-induced apoptosis in cancer

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21 January 2018

Ectopic expression of Bcl-2 and Bcl-xL inhibits apoptosis induced by TNF-related apoptosis-inducing ligand (TRAIL) through suppression of caspases-8, 7, and 3 and BID cleavage in human acute myelogenous leukemia cell line HL-60.

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21 January 2018

Increased expression of Mcl-1 is responsible for the blockage of TRAIL-induced apoptosis mediated by EGF/ErbB1 signaling pathway

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21 January 2018

Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.

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21 January 2018

Telomerase-dependent virotherapy overcomes resistance of hepatocellular carcinomas against chemotherapy and tumor necrosis factor-related apoptosis-inducing ligand by elimination of Mcl-1.

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21 January 2018

Interrelated roles for Mcl-1 and BIM in regulation of TRAIL-mediated mitochondrial apoptosis

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21 January 2018

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

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21 January 2018

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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21 January 2018

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

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21 January 2018

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

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21 January 2018

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

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21 January 2018

Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy

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From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance

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TRAIL/Apo2L activates c-Jun NH2-terminal kinase (JNK) via caspase-dependent and caspase-independent pathways

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Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways

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JNK/SAPK activity contributes to TRAIL-induced apoptosis

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JNK (c-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: differential requirements for caspase activation

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21 January 2018

TRAIL-induced apoptosis in gliomas is enhanced by Akt-inhibition and is independent of JNK activation

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Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand

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Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis

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TRAIL-induced death of human adult oligodendrocytes is mediated by JNK pathway.

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TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality.

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Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation

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TRAIL receptor-2 signals apoptosis through FADD and caspase-8

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FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

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The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation

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Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

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21 January 2018

Reutilization of Immunoblots after Chemiluminescent Detection

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21 January 2018

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