(Q34791120)

4 August 2017

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title

Targeting death and decoy receptors of the tumour-necrosis factor superfamily (English)

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4 August 2017

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Avi Ashkenazi

1

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4 August 2017

language of work or name

English

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publication date

1 June 2002

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4 August 2017

published in

Nature Reviews Cancer

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4 August 2017

volume

2

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4 August 2017

issue

6

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4 August 2017

page(s)

420-430

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An endotoxin-induced serum factor that causes necrosis of tumors

4 August 2017

cites work

1 reference

Effect of tumour necrosis factor on cultured human melanoma cells

31 March 2020

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Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

31 March 2020

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Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity

31 March 2020

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Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

31 March 2020

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Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface

31 March 2020

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Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon

31 March 2020

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cDNA sequences of two inducible T-cell genes

31 March 2020

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Expression and structure of the human NGF receptor

31 March 2020

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The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death

31 March 2020

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Identification and characterization of a new member of the TNF family that induces apoptosis

31 March 2020

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Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family

31 March 2020

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Death receptors: signaling and modulation

31 March 2020

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Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency

31 March 2020

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BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF

31 March 2020

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A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis

31 March 2020

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The TNF and TNF receptor superfamilies: integrating mammalian biology

31 March 2020

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A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL

31 March 2020

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2 A crystal structure of an extracellular fragment of human CD40 ligand

31 March 2020

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Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity

31 March 2020

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TNF alpha and the TNF receptor superfamily: structure-function relationship(s).

31 March 2020

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FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

31 March 2020

1 reference

Self-association of the Death Domains of the p55 Tumor Necrosis Factor (TNF) Receptor and Fas/APO1 Prompts Signaling for TNF and Fas/APO1 Effects

31 March 2020

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The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

31 March 2020

1 reference

The Bcl-2 protein family: arbiters of cell survival

31 March 2020

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Apoptotic pathways: paper wraps stone blunts scissors

31 March 2020

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Virology. A molecular whodunit

31 March 2020

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

31 March 2020

1 reference

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

31 March 2020

1 reference

Tumor necrosis factor receptor and Fas signaling mechanisms.

31 March 2020

1 reference

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

31 March 2020

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Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL.

31 March 2020

1 reference

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

31 March 2020

1 reference

A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis

31 March 2020

1 reference

TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator

31 March 2020

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TNF registered in Europe: does TNF get a second chance?

31 March 2020

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The effects of limb perfusion with tumor necrosis factor on circulating levels of proinflammatory cytokines

31 March 2020

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Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy

31 March 2020

1 reference

Tumor necrosis factor induces tumor necrosis via tumor necrosis factor receptor type 1-expressing endothelial cells of the tumor vasculature

31 March 2020

1 reference

The receptor for the cytotoxic ligand TRAIL

31 March 2020

1 reference

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

31 March 2020

1 reference

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

31 March 2020

1 reference

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

31 March 2020

1 reference

A novel receptor for Apo2L/TRAIL contains a truncated death domain

31 March 2020

1 reference

Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family

31 March 2020

1 reference

The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain

31 March 2020

1 reference

Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor

31 March 2020

1 reference

Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice

31 March 2020

1 reference

Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development

31 March 2020

1 reference

REGULATION OF APO-2 LIGAND/TRAIL EXPRESSION IN NK CELLS—INVOLVEMENT IN NK CELL-MEDIATED CYTOTOXICITY

31 March 2020

1 reference

Monocyte-mediated tumoricidal activity via the tumor necrosis factor-related cytokine, TRAIL.

31 March 2020

1 reference

Surface expression of TRAIL/Apo-2 ligand in activated mouse T and B cells

31 March 2020

1 reference

TRAIL/Apo-2-ligand-induced apoptosis in human T cells.

31 March 2020

1 reference

Involvement of APO2 ligand/TRAIL in activation-induced death of Jurkat and human peripheral blood T cells

31 March 2020

1 reference

Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs

31 March 2020

1 reference

Apo2L/TRAIL and Bcl-2-related proteins regulate type I interferon-induced apoptosis in multiple myeloma

31 March 2020

1 reference

Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL.

31 March 2020

1 reference

Genomic organization and transcriptional regulation of human Apo2/TRAIL gene.

31 March 2020

1 reference

Reovirus-induced apoptosis is mediated by TRAIL

31 March 2020

1 reference

Human herpesvirus 7 induces the functional up-regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) coupled to TRAIL-R1 down-modulation in CD4(+) T cells

31 March 2020

1 reference

Antiviral response by natural killer cells through TRAIL gene induction by IFN-alpha/beta

31 March 2020

1 reference

Differential secretion of Fas ligand- or APO2 ligand/TNF-related apoptosis-inducing ligand-carrying microvesicles during activation-induced death of human T cells

31 March 2020

1 reference

Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5

31 March 2020

1 reference

Cysteine 230 is essential for the structure and activity of the cytotoxic ligand TRAIL

31 March 2020

1 reference

Safety and antitumor activity of recombinant soluble Apo2 ligand

31 March 2020

1 reference

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

31 March 2020

1 reference

APO2 ligand: a novel lethal weapon against malignant glioma?

31 March 2020

1 reference

TRAIL is a potent inducer of apoptosis in myeloma cells derived from multiple myeloma patients and is not cytotoxic to hematopoietic stem cells

31 March 2020

1 reference

Apoptosis control by death and decoy receptors

31 March 2020

1 reference

TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications

31 March 2020

1 reference

Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity.

31 March 2020

1 reference

Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy

31 March 2020

1 reference

Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4

31 March 2020

1 reference

Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity.

31 March 2020

1 reference

Monoclonal antibody-mediated tumor regression by induction of apoptosis.

31 March 2020

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Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions

31 March 2020

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Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

31 March 2020

1 reference

Avoiding premature apoptosis of normal epidermal cells

31 March 2020

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The tumor necrosis factor-related apoptosis-inducing ligand receptors TRAIL-R1 and TRAIL-R2 have distinct cross-linking requirements for initiation of apoptosis and are non-redundant in JNK activation

31 March 2020

1 reference

A matter of life and cell death

31 March 2020

1 reference

Mechanisms of resistance of normal cells to TRAIL induced apoptosis vary between different cell types

31 March 2020

1 reference

Rel/NF-kappaB transcription factors protect against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by up-regulating the TRAIL decoy receptor DcR1

31 March 2020

1 reference

Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster

31 March 2020

1 reference

Amplification and expression of a decoy receptor for fas ligand (DcR3) in virus (EBV or HTLV-I) associated lymphomas

31 March 2020

1 reference

Apoptosis by death factor

31 March 2020

1 reference

Inhibition of death receptor signaling by FLICE-inhibitory protein as a mechanism for immune escape of tumors

31 March 2020

1 reference

Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein

31 March 2020

1 reference

The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors

31 March 2020

1 reference

Fas transduces activation signals in normal human T lymphocytes

31 March 2020

1 reference

Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway

31 March 2020

1 reference

The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells

31 March 2020

1 reference

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

31 March 2020

1 reference

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

31 March 2020

1 reference

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

31 March 2020

1 reference

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

31 March 2020

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

31 March 2020

1 reference

Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling

31 March 2020

1 reference

Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.

31 March 2020

1 reference

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

31 March 2020

1 reference

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

31 March 2020

1 reference

Role of BAX in the apoptotic response to anticancer agents

31 March 2020

1 reference

Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.

31 March 2020

1 reference

TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.

31 March 2020

1 reference

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

31 March 2020

1 reference

Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation

31 March 2020

1 reference

Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

31 March 2020

1 reference

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

31 March 2020

1 reference

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

31 March 2020

1 reference

Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

31 March 2020

1 reference

Caspase-10 is an initiator caspase in death receptor signaling

31 March 2020

1 reference

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

31 March 2020

1 reference

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

31 March 2020

1 reference

Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95

31 March 2020

1 reference

Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B

31 March 2020

1 reference

A death-domain-containing receptor that mediates apoptosis

31 March 2020

1 reference

Identification and functional characterization of DR6, a novel death domain-containing TNF receptor

31 March 2020

1 reference

Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice

31 March 2020

1 reference

Phase II studies of recombinant human tumor necrosis factor alpha in patients with malignant disease: a summary of the Southwest Oncology Group experience

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC821

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Dimensions Publication ID

4 August 2017

1047196539

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