(Q48548442)

12 February 2018

title

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. (English)

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12 February 2018

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1

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12 February 2018

Klaus-Michael Debatin

series ordinal

4

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12 February 2018

Michael Weller

series ordinal

3

object named as

Michael Weller

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12 February 2018

2

Wolfgang Wick

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PubMed ID

12118245

12 February 2018

language of work or name

English

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publication date

15 July 2002

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12 February 2018

published in

Nature Medicine

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12 February 2018

volume

8

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12 February 2018

page(s)

808-815

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12 February 2018

issue

8

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12 February 2018

https://scigraph.springernature.com/pub.10.1038/nm735

exact match

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cites work

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The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems

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Caspases: enemies within

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Two CD95 (APO-1/Fas) signaling pathways

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Mitochondrial control of cell death

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Cross-talk in cell death signaling

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The Bcl-2 protein family

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7 January 2021

Cell death inhibition: keeping caspases in check

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7 January 2021

IAP family proteins--suppressors of apoptosis

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7 January 2021

Expression and biological activity of X-linked inhibitor of apoptosis (XIAP) in human malignant glioma.

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7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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7 January 2021

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

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7 January 2021

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

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7 January 2021

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

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7 January 2021

Apoptotic pathways: paper wraps stone blunts scissors

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7 January 2021

Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression.

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7 January 2021

Structural basis of IAP recognition by Smac/DIABLO

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7 January 2021

Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the absence of neurotoxicity.

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MHC haplotype-dependent regulation of MOG-induced EAE in rats.

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Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

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Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4

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Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

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7 January 2021

Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions

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7 January 2021

Safety and antitumor activity of recombinant soluble Apo2 ligand

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The potential of TRAIL for cancer chemotherapy

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Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity.

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TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.

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7 January 2021

Role of BAX in the apoptotic response to anticancer agents

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7 January 2021

Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.

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7 January 2021

TRAIL/Apo-2-ligand-induced apoptosis in human T cells.

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Improved culture methods to expand Schwann cells with altered growth behaviour from CMT1A patients

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Cell-penetrating peptides.

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7 January 2021

Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway

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7 January 2021

Identifiers

DOI

10.1038/NM735

1 reference

12 February 2018

PubMed ID

12118245

1 reference

12 February 2018