(Q36999097)

17 August 2017

1 reference

title

The von hippel-lindau tumor suppressor protein: an update (English)

1 reference

17 August 2017

1

William G Kaelin

1 reference

17 August 2017

language of work or name

English

0 references

publication date

1 January 2007

1 reference

17 August 2017

published in

Methods in Enzymology

1 reference

17 August 2017

volume

435

1 reference

17 August 2017

page(s)

371-383

1 reference

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

17 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

The roles of cilia in developmental disorders and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

von Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Chat in the trophic web: NGF activates Ret by inter-RTK signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Expression of fibronectin and HIF-1alpha in renal cell carcinomas: relationship to von Hippel-Lindau gene inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Priming-dependent phosphorylation and regulation of the tumor suppressor pVHL by glycogen synthase kinase 3.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

A molecular basis for stabilization of the von Hippel-Lindau (VHL) tumor suppressor protein by components of the VHL ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Expression of hypoxia inducible factor-1alpha and 2alpha in genetically distinct early renal cortical tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Role of VHL gene mutation in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Focus on kidney cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Primary cilium formation requires von hippel-lindau gene function in renal-derived cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Inactivation of von Hippel-Lindau gene induces constitutive phosphorylation of MET protein in clear cell renal carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Recent insights into the molecular pathogenesis of pheochromocytoma and paraganglioma

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Direct Interaction of the β-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C zeta

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Von Hippel-Lindau-dependent polycythemia is endemic on the island of Ischia: identification of a novel cluster.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

p53 stabilization and transactivation by a von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

The primary cilium as the cell's antenna: signaling at a sensory organelle

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Expression of p53 in renal carcinoma cells is independent of pVHL.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

pVHL function is essential for endothelial extracellular matrix deposition.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935019-2

7 January 2021

10.1016/S0076-6879(07)35019-2

Identifiers

DOI

1 reference

17 August 2017

1 reference