(Q28285182)

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The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma

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title

The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma (English)

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William G Kaelin

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language of work or name

English

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publication date

15 January 2007

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published in

Clinical Cancer Research

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volume

13

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page(s)

680s-684s

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issue

2 Pt 2

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cites work

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Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma

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VHL expression in renal cell carcinoma sensitizes to bortezomib (PS-341) through an NF-kappaB-dependent mechanism.

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Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice

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Increased nuclear factor-kappa B activation is related to the tumor development of renal cell carcinoma.

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

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Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

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Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor.

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HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

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Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

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Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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Tumour suppression by the human von Hippel-Lindau gene product

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The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

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Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity

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Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

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Up-regulation of c-met protooncogene product expression through hypoxia-inducible factor-1alpha is involved in trophoblast invasion under low-oxygen tension

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Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

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Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma

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Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

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Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

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Constitutive activation of nuclear factor-kappaB prevents TRAIL-induced apoptosis in renal cancer cells.

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Role of VHL gene mutation in human cancer

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Molecular basis of the VHL hereditary cancer syndrome

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Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

Renal cell carcinoma risk in type 2 von Hippel-Lindau disease correlates with defects in pVHL stability and HIF-1alpha interactions.

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12 October 2022

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Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis

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12 October 2022

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A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets.

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12 October 2022

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Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1alpha in human salivary gland cancer cells.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

Hsp90 inhibitors as novel cancer chemotherapeutic agents

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Attenuation of proteasome-induced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}-methylbutyrate in cancer-induced muscle loss

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

von Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

Direct Interaction of the β-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

A conserved family of prolyl-4-hydroxylases that modify HIF

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

Hypoxia of the renal medulla--its implications for disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/1078-0432.CCR-06-1865

(Q28285182)

The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma

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