(Q39154743)

9 September 2017

Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases (English)

1 reference

9 September 2017

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Kamil Paruch

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Michael P Dwyer

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Carmen Alvarez

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Courtney Brown

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Tin-Yau Chan

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Ronald J Doll

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Kerry Keertikar

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Chad Knutson

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Brian McKittrick

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Jocelyn Rivera

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Randall Rossman

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Greg Tucker

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Alan Hruza

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Vincent Madison

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Amin A Nomeir

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Yaolin Wang

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Paul Kirschmeier

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Emma Lees

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

David Parry

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Nicole Sgambellone

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Wolfgang Seghezzi

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Lesley Schultz

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Frances Shanahan

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Derek Wiswell

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Xiaoying Xu

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Quiao Zhou

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Ray A James

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Vidyadhar M Paradkar

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Haengsoon Park

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Laura R Rokosz

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Tara M Stauffer

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Timothy J Guzi

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

language of work or name

1 reference

17 May 2010

1 reference

ACS Medicinal Chemistry Letters

9 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

204-208

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor.

7 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Progress in the evaluation of CDK inhibitors as anti-tumor agents

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

CDK inhibitors in cancer therapy: what is next?

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Cyclin-dependent kinase 5 (Cdk5): a potential therapeutic target for the treatment of neurodegenerative diseases and diabetes mellitus

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Structure-guided discovery of cyclin-dependent kinase inhibitors

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Flavopiridol in the treatment of chronic lymphocytic leukemia

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Cyclin-dependent kinase pathways as targets for cancer treatment

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

10 September 2017

Recycling the Cell Cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Regulation of RNA polymerase II activity by CTD phosphorylation and cell cycle control

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

S and G2 phase roles for Cdk2 revealed by inducible expression of a dominant-negative mutant in human cells

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Cell cycle regulation and RNA polymerase II.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Distinct roles for cyclin-dependent kinases in cell cycle control

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Unmasking the redundancy between Cdk1 and Cdk2 at G2 phase in human cancer cell lines

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

The cell cycle and the retinoblastoma protein family

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Regulation of the cell cycle by the Rb tumor suppressor family

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007794

Recycling the cell cycle: cyclins revisited

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900195

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML100051D

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900195%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference