(Q39165050)

9 September 2017

title

mTOR inhibitors radiosensitize PTEN-deficient non-small-cell lung cancer cells harboring an EGFR activating mutation by inducing autophagy (English)

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9 September 2017

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Eun Ju Kim

1

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9 September 2017

Jae-Hoon Jeong

2

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9 September 2017

Sangwoo Bae

3

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9 September 2017

Seongman Kang

4

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9 September 2017

Cheol Hyeon Kim

5

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9 September 2017

Young-Bin Lim

6

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9 September 2017

publication date

1 June 2013

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Journal of Cellular Biochemistry

9 September 2017

published in

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9 September 2017

volume

114

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9 September 2017

issue

6

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9 September 2017

page(s)

1248-1256

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Inhibition of mTOR pathway by everolimus cooperates with EGFR inhibitors in human tumours sensitive and resistant to anti-EGFR drugs

9 September 2017

cites work

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The TOR pathway: a target for cancer therapy

21 January 2018

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Mechanisms of mTOR inhibitor resistance in cancer therapy

21 January 2018

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The mTOR inhibitor rapamycin suppresses DNA double-strand break repair

21 January 2018

1 reference

Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation.

21 January 2018

1 reference

Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death

21 January 2018

1 reference

Promotion of autophagy as a mechanism for radiation sensitization of breast tumor cells

21 January 2018

1 reference

The potential role of mTOR inhibitors in non-small cell lung cancer

21 January 2018

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21 January 2018

The Beclin 1 interactome

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Antitumor activity of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib (ZD1839, Iressa) in non-small cell lung cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels

21 January 2018

1 reference

Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidyl inositol-3 kinase pathways in non-small cell lung cancer cells.

21 January 2018

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

21 January 2018

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Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to gefitinib (IRESSA).

21 January 2018

1 reference

Autophagy and the integrated stress response

21 January 2018

1 reference

Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC.

21 January 2018

1 reference

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

21 January 2018

1 reference

Antiangiogenic therapy with mammalian target of rapamycin inhibitor RAD001 (Everolimus) increases radiosensitivity in solid cancer

21 January 2018

1 reference

Methods for monitoring autophagy

21 January 2018

1 reference

The role of the Atg1/ULK1 complex in autophagy regulation

21 January 2018

1 reference

How to interpret LC3 immunoblotting

21 January 2018

1 reference

Methods in mammalian autophagy research

21 January 2018

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Cytoprotective roles for autophagy

21 January 2018

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Inducible EGFR T790M-mediated gefitinib resistance in non-small cell lung cancer cells does not modulate sensitivity to PI103 provoked autophagy

21 January 2018

1 reference

PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy.

21 January 2018

1 reference

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

21 January 2018

1 reference

PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR

21 January 2018

1 reference

Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions

21 January 2018

1 reference

Regulation of autophagy by cytoplasmic p53

21 January 2018

1 reference

Enhancing mTOR-targeted cancer therapy

21 January 2018

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Understanding resistance to EGFR inhibitors-impact on future treatment strategies

21 January 2018

1 reference

The role of autophagy in sensitizing malignant glioma cells to radiation therapy

21 January 2018

1 reference

Radiation-induced autophagy in normal and cancer cells: towards novel cytoprotection and radio-sensitization policies?

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/JCB.24465

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release_ddnlmmexk5habpr35ukqk2rxxe

9 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ddnlmmexk5habpr35ukqk2rxxe

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference