(Q39169274)

9 September 2017

Integration of parallel 13 C-labeling experiments and in silico pathway analysis for enhanced production of ascomycin (English)

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9 September 2017

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Haishan Qi

1

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9 September 2017

Mengmeng Lv

series ordinal

2

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9 September 2017

Kejing Song

series ordinal

3

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9 September 2017

Jianping Wen

series ordinal

4

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9 September 2017

21 November 2016

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Biotechnology and Bioengineering

9 September 2017

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9 September 2017

114

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9 September 2017

5

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9 September 2017

1036-1044

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Parallel labeling experiments with [1,2-(13)C]glucose and [U-(13)C]glutamine provide new insights into CHO cell metabolism

9 September 2017

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Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

21 January 2018

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Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements.

21 January 2018

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Parallel labeling experiments validate Clostridium acetobutylicum metabolic network model for (13)C metabolic flux analysis.

21 January 2018

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Systems-wide analysis and engineering of metabolic pathway fluxes in bio-succinate producing Basfia succiniciproducens

21 January 2018

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Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

21 January 2018

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Carbon-flux distribution within Streptomyces coelicolor metabolism: a comparison between the actinorhodin-producing strain M145 and its non-producing derivative M1146.

21 January 2018

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Integration of in vivo and in silico metabolic fluxes for improvement of recombinant protein production

21 January 2018

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Rapid metabolic analysis of Rhodococcus opacus PD630 via parallel 13C-metabolite fingerprinting

21 January 2018

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Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement

21 January 2018

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Pimecrolimus 1% cream in the treatment of facial psoriasis: a 16-week open-label study

21 January 2018

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Metabolic flux analysis for calcium dependent antibiotic (CDA) production in Streptomyces coelicolor

21 January 2018

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Reconstruction of a high-quality metabolic model enables the identification of gene overexpression targets for enhanced antibiotic production in Streptomyces coelicolor A3(2).

21 January 2018

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Parallel labeling experiments with [U-13C]glucose validate E. coli metabolic network model for 13C metabolic flux analysis

21 January 2018

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COMPLETE-MFA: complementary parallel labeling experiments technique for metabolic flux analysis.

21 January 2018

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Rational improvement of the engineered isobutanol-producing Bacillus subtilis by elementary mode analysis

21 January 2018

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Flux Design: In silico design of cell factories based on correlation of pathway fluxes to desired properties

21 January 2018

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Antimalarial effects of macrolactones related to FK520 (ascomycin) are independent of the immunosuppressive properties of the compounds

21 January 2018

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In-silico-driven metabolic engineering of Pseudomonas putida for enhanced production of poly-hydroxyalkanoates

21 January 2018

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Inactivation of pycA, encoding pyruvate carboxylase activity, increases poly-beta-hydroxybutyrate accumulation in Azotobacter vinelandii on solid medium

21 January 2018

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Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectants

21 January 2018

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Metabolic network reconstruction, growth characterization and 13C-metabolic flux analysis of the extremophile Thermus thermophilus HB8.

21 January 2018

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Rational design and construction of an efficient E. coli for production of diapolycopendioic acid

21 January 2018

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Engineering Scheffersomyces stipitis for fumaric acid production from xylose

21 January 2018

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The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.

21 January 2018

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Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis.

21 January 2018

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Application of a double-reporter-guided mutant selection method to improve clavulanic acid production in Streptomyces clavuligerus.

21 January 2018

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Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line

21 January 2018

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An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis.

21 January 2018

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Elementary flux modes in a nutshell: properties, calculation and applications.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIT.26223

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9 September 2017

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