(Q39173063)

17 June 2018

title

Catalytic promiscuity and heme-dependent redox regulation of H2S synthesis (English)

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17 June 2018

author name string

Ruma Banerjee

series ordinal

1

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17 June 2018

publication date

7 March 2017

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17 June 2018

Current Opinion in Chemical Biology

published in

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17 June 2018

volume

37

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17 June 2018

page(s)

115-121

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17 June 2018

Thioethers as markers of hydrogen sulfide production in homocystinurias.

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Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response

22 June 2018

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S-Adenosyl-l-methionine Modulates CO and NO• Binding to the Human H2S-generating Enzyme Cystathionine β-Synthase

22 June 2018

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Retracted: Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium

22 June 2018

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Protein kinase G-regulated production of H2S governs oxygen sensing

22 June 2018

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S-glutathionylation enhances human cystathionine β-synthase activity under oxidative stress conditions.

22 June 2018

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Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

22 June 2018

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NO* binds human cystathionine β-synthase quickly and tightly

22 June 2018

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Nitrite reductase activity and inhibition of H₂S biogenesis by human cystathionine ß-synthase

22 June 2018

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Structure and Kinetic Analysis of H2S Production by Human Mercaptopyruvate Sulfurtransferase

22 June 2018

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Enzymology of H2S biogenesis, decay and signaling

22 June 2018

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Metabolite damage and its repair or pre-emption

22 June 2018

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Reversible heme-dependent regulation of human cystathionine β-synthase by a flavoprotein oxidoreductase.

22 June 2018

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PLP-dependent H(2)S biogenesis

22 June 2018

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The quantitative significance of the transsulfuration enzymes for H2S production in murine tissues

22 June 2018

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22 June 2018

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Redox biochemistry of hydrogen sulfide

22 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Enzyme promiscuity: a mechanistic and evolutionary perspective

22 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Heme regulation of human cystathionine beta-synthase activity: insights from fluorescence and Raman spectroscopy

22 June 2018

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Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions

22 June 2018

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H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylation

22 June 2018

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Reversible compartmentalization of de novo purine biosynthetic complexes in living cells

22 June 2018

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Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Thioredoxin-dependent enzymatic activation of mercaptopyruvate sulfurtransferase. An intersubunit disulfide bond serves as a redox switch for activation

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Characterization of human D-amino acid oxidase

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Evolution of hormone-receptor complexity by molecular exploitation

22 June 2018

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Dynamics of carbon monoxide binding to cystathionine beta-synthase

22 June 2018

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Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS

22 June 2018

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The 'evolvability' of promiscuous protein functions

22 June 2018

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Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine

22 June 2018

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A new activity for an old enzyme: Escherichia coli bacterial alkaline phosphatase is a phosphite-dependent hydrogenase

22 June 2018

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PATHWAYS AND REGULATION OF SULFUR METABOLISM REVEALED THROUGH MOLECULAR AND GENETIC STUDIES.

22 June 2018

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HOMOCYSTINURIA: AN ENZYMATIC DEFECT.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Sulfur metabolism in Escherichia coli and related bacteria: facts and fiction.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Tissue and subcellular distribution of mercaptopyruvate sulfurtransferase in the rat: confocal laser fluorescence and immunoelectron microscopic studies combined with biochemical analysis

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

The specific features of methionine biosynthesis and metabolism in plants.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

The structure of a domain common to archaebacteria and the homocystinuria disease protein

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Role of amino acid residues in the active site of rat liver mercaptopyruvate sulfurtransferase. CDNA cloning, overexpression, and site-directed mutagenesis

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Purification and characterization of cysteine aminotransferase from rat liver cytosol

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Homolanthionine excretion in homocystinuria

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Enzyme recruitment in evolution of new function

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Purification and characterization of mitochondrial cysteine aminotransferase from rat liver

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Heme-dependent Metabolite Switching Regulates H2S Synthesis in Response to Endoplasmic Reticulum (ER) Stress.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Dioxygen reactivity and heme redox potential of truncated human cystathionine beta-synthase

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Endoplasmic reticulum stress stimulates heme oxygenase-1 gene expression in vascular smooth muscle. Role in cell survival

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Mercuric chloride-induced spin or ligation state changes in ferric or ferrous human cystathionine beta-synthase inhibit enzyme activity

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Characterization of NO binding to human cystathionine beta-synthase: possible implications of the effects of CO and NO binding to the human enzyme

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine beta-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5410396

Enzymatic desulfuration of beta-mercaptopyruvate to pyruvate

21 August 2018

1 reference

12 December 2020

Cysteine sulfinate aminotransferase and aspartate aminotransferase isoenzymes of rat brain. Purification, characterization, and further evidence for identity

1 reference

12 December 2020

Beta mercaptolactate-cysteine disulfide: analog of cystine in the urine of a mentally retarded patient

1 reference

12 December 2020

Inhibitory effect of mercaptoethanol and hypotaurine on the desulfhydration of cysteine by cystathionase

1 reference

12 December 2020

Hepatocyte-catalysed detoxification of cyanide by L- and D-cysteine

1 reference

12 December 2020

Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites

1 reference

12 December 2020

Underground metabolism

1 reference

12 December 2020

10.1016/J.CBPA.2017.02.021

Identifiers

DOI

1 reference

17 June 2018

PMC publication ID

5410396

1 reference

17 June 2018

PubMed publication ID

28282633

1 reference

17 June 2018