(Q39176245)

English

Metformin enhances cisplatin cytotoxicity by suppressing signal transducer and activator of transcription-3 activity independently of the liver kinase B1-AMP-activated protein kinase pathway.

scientific article published on August 2013

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27 February 2020

Metformin enhances cisplatin cytotoxicity by suppressing signal transducer and activator of transcription-3 activity independently of the liver kinase B1-AMP-activated protein kinase pathway (English)

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27 February 2020

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Chien-Chung Lin

1

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27 February 2020

author name string

Hsuan-Heng Yeh

2

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27 February 2020

Wei-Lun Huang

3

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27 February 2020

Jing-Jou Yan

4

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27 February 2020

Wu-Wei Lai

5

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27 February 2020

Wen-Pin Su

6

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27 February 2020

Helen H W Chen

7

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27 February 2020

Wu-Chou Su

8

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27 February 2020

publication date

1 August 2013

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27 February 2020

American Journal of Respiratory Cell and Molecular Biology

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27 February 2020

49

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27 February 2020

2

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27 February 2020

241-250

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27 February 2020

Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Metformin: a therapeutic opportunity in breast cancer

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Metformin: taking away the candy for cancer?

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

TSC2 mediates cellular energy response to control cell growth and survival

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

The STATs of cancer--new molecular targets come of age

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

One hundred years of lung cancer

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion.

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Cancer stem cell radioresistance and enrichment: where frontline radiation therapy may fail in lung and esophageal cancers

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Tumor volume in subcutaneous mouse xenografts measured by microCT is more accurate and reproducible than determined by 18F-FDG-microPET or external caliper

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth.

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Malignant pleural effusion cells show aberrant glucose metabolism gene expression

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3).

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cells

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Metformin reduces endogenous reactive oxygen species and associated DNA damage

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Utility of metformin in breast cancer treatment, is neoangiogenesis a risk factor?

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Prognostic significance of STAT3 expression and its correlation with chemoresistance of non-small cell lung cancer cells

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Vaspin prevents TNF-α-induced intracellular adhesion molecule-1 via inhibiting reactive oxygen species-dependent NF-κB and PKCθ activation in cultured rat vascular smooth muscle cells.

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2012-0244OC

21 January 2018

Identifiers

10.1165/RCMB.2012-0244OC

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23526220%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23526220%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

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