(Q39177084)

9 September 2017

title

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation (English)

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9 September 2017

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Xavier Deschênes-Simard

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author name string

Olga Moiseeva

1

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9 September 2017

Emmanuelle St-Germain

3

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9 September 2017

Sebastian Igelmann

4

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9 September 2017

Geneviève Huot

5

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9 September 2017

Alexandra E Cadar

6

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9 September 2017

Véronique Bourdeau

7

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9 September 2017

Michael N Pollak

8

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9 September 2017

Gerardo Ferbeyre

9

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9 September 2017

publication date

23 April 2013

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9 September 2017

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9 September 2017

volume

12

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9 September 2017

issue

3

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9 September 2017

page(s)

489-498

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Motif module map reveals enforcement of aging by continual NF-kappaB activity

9 September 2017

cites work

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If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

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Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis.

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Inflamm-aging of the stem cell niche: breast cancer as a paradigmatic example: breakdown of the multi-shell cytokine network fuels cancer in aged people

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Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity

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The senescence-associated secretory phenotype: the dark side of tumor suppression

21 January 2018

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Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans

21 January 2018

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The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4

21 January 2018

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Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene.

21 January 2018

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Coxibs and other nonsteroidal anti-inflammatory drugs in animal models of cancer chemoprevention

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The mitochondrial ATPase inhibitory factor 1 triggers a ROS-mediated retrograde prosurvival and proliferative response

21 January 2018

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DNA damage-mediated induction of a chemoresistant niche

21 January 2018

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Clinical Pharmacokinetics of Metformin

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Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

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The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation

21 January 2018

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Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations

21 January 2018

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Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats

21 January 2018

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Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

21 January 2018

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Lymphocyte-suppressing and systemic anti-inflammatory effects of high-dose metformin in simvastatin-treated patients with impaired fasting glucose.

21 January 2018

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Glucocorticoids suppress selected components of the senescence-associated secretory phenotype

21 January 2018

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Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b)

21 January 2018

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Babelomics: an integrative platform for the analysis of transcriptomics, proteomics and genomic data with advanced functional profiling

21 January 2018

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Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis

21 January 2018

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IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

21 January 2018

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RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12075

Mitochondrial dysfunction contributes to oncogene-induced senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12075

Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS)

21 January 2018

1 reference

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Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

21 January 2018

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PDGF receptors as cancer drug targets

21 January 2018

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Metformin and other biguanides in oncology: advancing the research agenda

21 January 2018

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Investigating metformin for cancer prevention and treatment: the end of the beginning

21 January 2018

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21 January 2018

Targeting PDK1 in cancer

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

21 January 2018

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Reconstructing eukaryotic NAD metabolism

21 January 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12075

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12075

NF-κB inhibition delays DNA damage-induced senescence and aging in mice

21 January 2018

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https://api.crossref.org/works/10.1111%2FACEL.12075

Regulation of E2Fs and senescence by PML nuclear bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FACEL.12075

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

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https://api.crossref.org/works/10.1111%2FACEL.12075

The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways

21 January 2018

1 reference

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The price of tumour suppression?

21 January 2018

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https://api.crossref.org/works/10.1111%2FACEL.12075

21 January 2018

Identifiers

DOI

10.1111/ACEL.12075

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9 September 2017

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