(Q39192241)

9 September 2017

title

Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity (English)

1 reference

9 September 2017

0 references

Toshimitsu Ohashi

1

1 reference

9 September 2017

Takashi Akazawa

2

1 reference

9 September 2017

Mitsuhiro Aoki

3

1 reference

9 September 2017

Bunya Kuze

4

1 reference

9 September 2017

Keisuke Mizuta

5

1 reference

9 September 2017

Yatsuji Ito

6

1 reference

9 September 2017

Norimitsu Inoue

7

1 reference

9 September 2017

language of work or name

English

0 references

publication date

16 March 2013

1 reference

International Journal of Cancer

9 September 2017

published in

1 reference

9 September 2017

volume

133

1 reference

9 September 2017

issue

5

1 reference

9 September 2017

page(s)

1107-1118

1 reference

Cancer-related inflammation

9 September 2017

cites work

1 reference

Immunity, Inflammation, and Cancer

21 January 2018

1 reference

Coordinated regulation of myeloid cells by tumours

21 January 2018

1 reference

T-regulatory cells: key players in tumor immune escape and angiogenesis

21 January 2018

1 reference

Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway

21 January 2018

1 reference

IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid.

21 January 2018

1 reference

IL-23 promotes tumour incidence and growth

21 January 2018

1 reference

Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment

21 January 2018

1 reference

Tumor-derived lactic acid modulates dendritic cell activation and antigen expression.

21 January 2018

1 reference

Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model

21 January 2018

1 reference

Lactate: a metabolic key player in cancer

21 January 2018

1 reference

Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis.

21 January 2018

1 reference

Tumor metabolism as modulator of immune response and tumor progression

21 January 2018

1 reference

Lactate stimulates endothelial cell migration.

21 January 2018

1 reference

Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis

21 January 2018

1 reference

Lactate: mirror and motor of tumor malignancy

21 January 2018

1 reference

Why do cancers have high aerobic glycolysis?

21 January 2018

1 reference

Cancer's molecular sweet tooth and the Warburg effect.

21 January 2018

1 reference

Regulation of cancer cell metabolism

21 January 2018

1 reference

Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

21 January 2018

1 reference

Therapeutic targets in cancer cell metabolism and autophagy

21 January 2018

1 reference

Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements

21 January 2018

1 reference

Constitutive class I-restricted exogenous presentation of self antigens in vivo

21 January 2018

1 reference

Adjuvant engineering for cancer immunotherapy: Development of a synthetic TLR2 ligand with increased cell adhesion

21 January 2018

1 reference

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

1 reference

Clinical pharmacology and toxicology of dichloroacetate

21 January 2018

1 reference

Tumor-infiltrating macrophages induce apoptosis in activated CD8(+) T cells by a mechanism requiring cell contact and mediated by both the cell-associated form of TNF and nitric oxide.

21 January 2018

1 reference

Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses

21 January 2018

1 reference

Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives

21 January 2018

1 reference

Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

21 January 2018

1 reference

Enhancer-mediated control of macrophage-specific arginase I expression

21 January 2018

1 reference

Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c(+)/CD8α(+) dendritic cells.

21 January 2018

1 reference

Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes

21 January 2018

1 reference

Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children

21 January 2018

1 reference

Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate

21 January 2018

1 reference

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

21 January 2018

1 reference

Dichloroacetate induces apoptosis in endometrial cancer cells.

21 January 2018

1 reference

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

21 January 2018

1 reference

Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC.

21 January 2018

1 reference

Metabolic modulation of glioblastoma with dichloroacetate

21 January 2018

1 reference

Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells

21 January 2018

1 reference

Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress

21 January 2018

1 reference

Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/IJC.28114

1 reference

9 September 2017

1 reference