(Q39218226)

English

A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-β and vascular endothelial growth factor signalling

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scholarly article

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10 September 2017

A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-β and vascular endothelial growth factor signalling (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 September 2017

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author name string

Yuqing Liu

1

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10 September 2017

Zhuo Wang

2

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10 September 2017

Jianing Wang

3

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10 September 2017

Wingchi Lam

4

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10 September 2017

Shuqin Kwong

5

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10 September 2017

Furong Li

6

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10 September 2017

Scott L Friedman

7

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10 September 2017

Shuyan Zhou

8

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10 September 2017

Qi Ren

9

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10 September 2017

Zhengshuang Xu

10

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10 September 2017

Xingen Wang

11

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10 September 2017

Ling Ji

12

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10 September 2017

Shoubin Tang

13

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10 September 2017

Hui Zhang

14

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10 September 2017

Eric L Lui

15

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10 September 2017

Tao Ye

16

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10 September 2017

publication date

26 December 2012

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10 September 2017

Liver International

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10 September 2017

33

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4

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10 September 2017

504-515

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10 September 2017

Mechanisms of hepatic fibrogenesis

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis.

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-beta soluble receptor: implications for antifibrotic therapy

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp.

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Total synthesis and biological evaluation of largazole and derivatives with promising selectivity for cancers cells

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib.

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis.

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Inhibition of rat liver fibrogenesis through noradrenergic antagonism

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Chronic administration of valproic acid inhibits activation of mouse hepatic stellate cells in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Epigenetic combination therapy as a tumor-selective treatment approach for hepatocellular carcinoma.

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Apoptosis on hepatoma cells but not on primary hepatocytes by histone deacetylase inhibitors valproate and ITF2357.

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Differential effects of histone deacetylase inhibitors in tumor and normal cells-what is the toxicological relevance?

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

TGF-beta1 modulates matrix metalloproteinase-13 expression in hepatic stellate cells by complex mechanisms involving p38MAPK, PI3-kinase, AKT, and p70S6k

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Sinusoidal remodeling and angiogenesis: a new function for the liver-specific pericyte?

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats.

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

The biology of VEGF and its receptors

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Coordinated induction of VEGF receptors in mesenchymal cell types during rat hepatic wound healing

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture

1 reference

https://api.crossref.org/works/10.1111%2FLIV.12034

21 January 2018

Identifiers

10.1111/LIV.12034

1 reference

Europe PubMed Central

PubMed publication ID

10 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 September 2017

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