(Q39224986)

10 September 2017

An activated JAK/STAT3 pathway and CD45 expression are associated with sensitivity to Hsp90 inhibitors in multiple myeloma (English)

1 reference

10 September 2017

Huiqiong Lin

1

1 reference

10 September 2017

Iryna Kolosenko

2

1 reference

10 September 2017

Ann-Charlotte Björklund

3

1 reference

10 September 2017

Darya Protsyuk

4

1 reference

10 September 2017

Anders Österborg

5

1 reference

10 September 2017

Dan Grandér

6

1 reference

10 September 2017

Katja Pokrovskaja Tamm

7

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10 September 2017

language of work or name

English

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publication date

13 December 2012

1 reference

Experimental Cell Research

10 September 2017

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10 September 2017

319

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10 September 2017

600-611

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10 September 2017

5

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Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets

10 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Autocrine interleukin-6 production and highly malignant multiple myeloma: relation with resistance to drug-induced apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Inhibition of heat shock protein 90 (HSP90) as a therapeutic strategy for the treatment of myeloma and other cancers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Signalling profile and antitumour activity of the novel Hsp90 inhibitor NVP-AUY922 in multiple myeloma.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Combined functional and molecular analysis of tumor cell signaling defines 2 distinct myeloma subgroups: Akt-dependent and Akt-independent multiple myeloma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

The magnitude of Akt/phosphatidylinositol 3'-kinase proliferating signaling is related to CD45 expression in human myeloma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

CD45neg but not CD45pos human myeloma cells are sensitive to the inhibition of IGF-1 signaling by a murine anti-IGF-1R monoclonal antibody, mAVE1642.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Interferon alpha-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

International staging system for multiple myeloma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Activation of STAT1 is required for interferon-alpha-mediated cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Analysis of expression of heat shock protein-90 (HSP90) and the effects of HSP90 inhibitor (17-AAG) in multiple myeloma.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Antimyeloma activity of heat shock protein-90 inhibition.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90alpha and beta in multiple myeloma cells, which critically contribute to tumor-cell survival

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

A cellular model for myeloma cell growth and maturation based on an intraclonal CD45 hierarchy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Normal and malignant human plasma cells: proliferation, differentiation, and expansions in relation to CD45 expression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

CD45 expression by bone marrow plasma cells in multiple myeloma: clinical and biological correlations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Interferon-alpha-induced apoptosis in U266 cells is associated with activation of the proapoptotic Bcl-2 family members Bak and Bax.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

Increased susceptibility to apoptosis in CD45(+) myeloma cells accompanied by the increased expression of VDAC1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.12.006

10.1016/J.YEXCR.2012.12.006

7 January 2021

Identifiers

DOI

1 reference

10 September 2017

1 reference