(Q39230907)

10 September 2017

1 reference

title

Flumazenil. A preliminary review of its benzodiazepine antagonist properties, intrinsic activity and therapeutic use. (English)

1 reference

10 September 2017

1

R N Brogden

1 reference

10 September 2017

K L Goa

2

1 reference

PubMed ID

2839329

10 September 2017

language of work or name

1 reference

1 April 1988

1 reference

10 September 2017

1 reference

10 September 2017

35

1 reference

10 September 2017

4

1 reference

10 September 2017

448-467

1 reference

https://scigraph.springernature.com/pub.10.2165/00003495-198835040-00004

10 September 2017

0 references

cites work

Kinetics and displacement of [11C]RO 15-1788, a benzodiazepine antagonist, studied in human brain in vivo by positron tomography.

1 reference

12 December 2020

Pharmacokinetics and clinical use of flumazenil (Ro 15-1788).

1 reference

12 December 2020

Benzodiazepine antagonist Ro 15-1788. Antagonism of diazepam sedation in outpatients undergoing gastroscopy

1 reference

12 December 2020

The anticonvulsant effect of the benzodiazepine antagonist, Ro 15-1788: an EEG study in 4 cases

1 reference

12 December 2020

Pharmacokinetics of the new benzodiazepine antagonist Ro 15-1788 in man following intravenous and oral administration

1 reference

12 December 2020

RO 15-1788 antagonises the central effects of diazepam in man without altering diazepam bioavailability

1 reference

12 December 2020

Does the benzodiazepine antagonist Ro 15-1788 antagonize the action of ethanol?

1 reference

12 December 2020

Effects of the benzodiazepine receptor ligands midazolam, Ro 15-1788, and Ro 5-4864, alone and in combinations, on platelet serotonin uptake

1 reference

12 December 2020

The anxiogenic action of Ro 15-1788 is reversed by chronic, but not by acute, treatment with chlordiazepoxide.

1 reference

12 December 2020

Weaning patients from mechanical ventilation by benzodiazepine antagonist Ro15-1788

1 reference

12 December 2020

Drug interactions at the GABA receptor-ionophore complex

1 reference

12 December 2020

The effects of a benzodiazepine antagonist Ro 15-1788 in the presence of stable concentrations of midazolam.

1 reference

12 December 2020

Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788.

1 reference

12 December 2020

Intracranial self-stimulation distinguishes between two benzodiazepine antagonists.

1 reference

12 December 2020

Investigation in man of the efficacy of a benzodiazepine antagonist, Ro 15-1788.

1 reference

12 December 2020

Benzodiazepine receptor occupancy in vivo: correlation with brain concentrations and pharmacodynamic actions.

1 reference

12 December 2020

Flumazenil in the management of acute drug overdosage with benzodiazepines and other agents

1 reference

12 December 2020

Flunitrazepam and lormetazepam do not affect the pharmacokinetics of the benzodiazepine antagonist Ro 15-1788

1 reference

12 December 2020

Self-regulation of ICSS duration: effects of anxiogenic substances, benzodiazepine antagonists and antidepressants.

1 reference

12 December 2020

Selective antagonists of benzodiazepines

1 reference

12 December 2020

Benzodiazepine antagonist Ro 15-1788 in self-poisoning

1 reference

12 December 2020

Absence of central effects in man of the benzodiazepine antagonist Ro 15-1788.

1 reference

12 December 2020

Determination of Ro 15-1788, a benzodiazepine antagonist, in human plasma by gas-liquid chromatography with nitrogen-phosphorus detection. Application to single-dose pharmacokinetic studies

1 reference

12 December 2020

Evaluation of visual function in healthy subjects after administration of Ro 15-1788

1 reference

12 December 2020

Flumazenil in benzodiazepine antagonism. Actions and clinical use in intoxications and anaesthesiology

1 reference

12 December 2020

Randomized clinical investigation of Ro 15-1788, a benzodiazepine antagonist, in reversing the central effects of flunitrazepam.

1 reference

12 December 2020

A three-state model of the benzodiazepine receptor explains the interactions between the benzodiazepine antagonist Ro 15-1788, benzodiazepine tranquilizers, ?-carbolines, and phenobarbitone

1 reference

12 December 2020

Highly sensitive assay of benzodiazepine antagonist in plasma by capillary gas chromatography with nitrogen-selective detection

1 reference

12 December 2020

Effects of diazepam on mitosis and basal body duplication of synchronously dividing flagellate cells

1 reference

12 December 2020

Pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 in man

1 reference

12 December 2020

Clinical evaluation of a specific benzodiazepine antagonist (RO 15-1788). Studies in elderly patients after regional anaesthesia under benzodiazepine sedation

1 reference

12 December 2020

Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists.

1 reference

12 December 2020

Double-blind study of the reversal of midazolam-supplemented general anaesthesia with Ro 15-1788.

1 reference

12 December 2020

Modern trends in the investigation of new hypnotics in anaesthesia.

1 reference

12 December 2020

Protection against the lethal effects of pentobarbital in mice by a benzodiazepine receptor inverse agonist, 6,7-dimethoxy-4-ethyl-3-carbomethoxy-beta-carboline

1 reference

12 December 2020

Agonist and antagonist benzodiazepine receptor interaction in vitro

1 reference

12 December 2020

Benzodiazepine receptor ligands with positive and negative efficacy

1 reference

12 December 2020

Reversal of hepatic coma by benzodiazepine antagonist (Ro 15-1788)

1 reference

12 December 2020

Is Ro15-1788 a partial agonist at benzodiazepine receptors?

1 reference

12 December 2020

The neuropharmacology of schistosomes

1 reference

12 December 2020

Interaction of Convulsive Ligands with Benzodiazepine Receptors

1 reference

12 December 2020

The Ro 15-1788 cue: evidence for benzodiazepine agonist and inverse agonist properties

1 reference

12 December 2020

Benzodiazepine antagonist (RO 15-1788) in ethanol intoxication: a pilot study

1 reference

12 December 2020

Reversal of benzodiazepine-induced sedation by intravenous Ro 15-1788.

1 reference

12 December 2020

Pharmacodynamic interaction between midazolam and a specific benzodiazepine antagonist in humans.

1 reference

12 December 2020

Investigation of the actions of the benzodiazepine antagonists Ro 15-1788 and CGS 8216 using the schedule-controlled behavior of rats.

1 reference

12 December 2020

Electrophysiological studies on the specific benzodiazepine antagonist Ro 15-1788.

1 reference

12 December 2020

Reversal of slow-wave sleep by benzodiazepine antagonist Ro 15-1788.

1 reference

12 December 2020

Benzodiazepine antagonist Ro 15-1788: Neurological and behavioral effects

1 reference

12 December 2020

Anxiogenic action of benzodiazepine antagonists Ro 15-1788 and CGS 8216 in the rat.

1 reference

12 December 2020

Benzodiazepine antagonist Ro 15-1788 in self-poisoning. Diagnostic and therapeutic use.

1 reference

12 December 2020

Apparent pA2 estimation of benzodiazepine receptor antagonists.

1 reference

12 December 2020

Ro 15-1788 antagonizes the effects of diazepam in man without affecting its bioavailability.

1 reference

12 December 2020

Withdrawal symptoms after six weeks' treatment with diazepam

1 reference

12 December 2020

Unusual interactions of benzodiazepine receptor antagonists.

1 reference

12 December 2020

Use of the specific benzodiazepine antagonist, Ro 15-1788, in studies of physiological dependence on benzodiazepines

1 reference

12 December 2020

The effects of the benzodiazepine antagonist Ro 15-1788 on psychophysiological performance and subjective measures in normal subjects.

1 reference

12 December 2020

Action of the benzodiazepine antagonist Ro 15-1788 in humans after sleep withdrawal.

1 reference

12 December 2020

Convulsions induced by submaximal dose of pentylenetetrazol in mice are antagonized by the benzodiazepine antagonist Ro 15-1788.

1 reference

12 December 2020

Chronic treatment with Ro 15-1788 distinguishes between its benzodiazepine antagonist, agonist and inverse agonist properties.

1 reference

12 December 2020

Ro 15-1788 for postoperative recovery. A randomised clinical trial in patients undergoing minor surgical procedures under midazolam anaesthesia

1 reference

12 December 2020

First Clinical Investigation of the Benzodiazepine Antagonist Ro 15-1788 in Comatose Patients

1 reference

12 December 2020

The partial benzodiazepine agonist properties of Ro 15-1788 in pentylenetetrazol-induced seizures in cats

1 reference

12 December 2020

Effects of a benzodiazepine antagonist on the diazepam-induced electrical brain activity modifications.

1 reference

12 December 2020

Behavioural evidence for partial agonist properties of RO 15-1788, a benzodiazepine receptor antagonist.

1 reference

12 December 2020

Effect of the benzodiazepine antagonist Ro 15-1788 on flunitrazepam- induced sleep changes

1 reference

12 December 2020

Effects of a specific benzodiazepine antagonist (RO 15-1788) on cerebral blood flow.

1 reference

12 December 2020

Benzodiazepine Antagonist Ro 15?1788: Binding Characteristics and Interaction with Drug-Induced Changes in Dopamine Turnover and Cerebellar cGMP Levels

1 reference

12 December 2020

Preclinical pharmacology of midazolam

1 reference

12 December 2020

Benzodiazepine receptors

1 reference

12 December 2020

Imaging of [11C]-labelled Ro 15-1788 binding to benzodiazepine receptors in the human brain by positron emission tomography

1 reference

12 December 2020

A novel pyrazoloquinoline that interacts with brain benzodiazepine receptors: Characterization of some and properties of CGS 9896

1 reference

12 December 2020

Intrinsic activity of the benzodiazepine antagonist Ro 15-1788 in man: an electrophysiological investigation.

1 reference

12 December 2020

10.2165/00003495-198835040-00004

Identifiers

DOI

1 reference

PubMed ID

2839329

Dimensions Publication ID

10 September 2017

0 references

1 reference

PubMed ID

2839329