(Q39250750)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

main subject

arterial hypertension

0 references

pulmonary hypertension

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

Michele M Hickey

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Theresa Richardson

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Tao Wang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Evguenia Arguiri

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Hongwei Yu

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Qian-Chun Yu

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Charalambos C Solomides

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Edward E Morrisey

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Tejvir S Khurana

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Melpo Christofidou-Solomidou

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

M Celeste Simon

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

language of work or name

English

0 references

publication date

8 February 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

number of pages

13

1 reference

Journal of Clinical Investigation

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

volume

120

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

page(s)

827-839

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

19 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2827942/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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1 reference

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von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis

10 September 2017

1 reference

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Pathogenesis of pulmonary edema: learning from high-altitude pulmonary edema

10 September 2017

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Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

10 September 2017

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Acute postnatal ablation of Hif-2alpha results in anemia

10 September 2017

1 reference

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10 September 2017

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Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms

10 September 2017

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Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo

10 September 2017

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10 September 2017

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Vascular complications in Chuvash polycythemia

10 September 2017

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pVHL function is essential for endothelial extracellular matrix deposition.

10 September 2017

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Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage

10 September 2017

1 reference

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Von Hippel-Lindau-dependent polycythemia is endemic on the island of Ischia: identification of a novel cluster.

10 September 2017

1 reference

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Reversal of experimental pulmonary hypertension by PDGF inhibition

10 September 2017

1 reference

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Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

10 September 2017

1 reference

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Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

10 September 2017

1 reference

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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

10 September 2017

1 reference

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A role for platelet-derived growth factor beta-receptor in a newborn rat model of endothelin-mediated pulmonary vascular remodeling

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Hypoxia, leukocytes, and the pulmonary circulation

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans

10 September 2017

1 reference

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Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis

10 September 2017

1 reference

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Cellular and molecular pathobiology of pulmonary arterial hypertension

10 September 2017

1 reference

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pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

10 September 2017

1 reference

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Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

10 September 2017

1 reference

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Targeting HIF-1 for cancer therapy

10 September 2017

1 reference

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Mutations of von Hippel-Lindau tumor-suppressor gene and congenital polycythemia.

10 September 2017

1 reference

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Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

10 September 2017

1 reference

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Molecular basis of the VHL hereditary cancer syndrome

10 September 2017

1 reference

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Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

10 September 2017

1 reference

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

10 September 2017

1 reference

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The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

10 September 2017

1 reference

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Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

10 September 2017

1 reference

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The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

10 September 2017

1 reference

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Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

10 September 2017

1 reference

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A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

10 September 2017

1 reference

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Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

10 September 2017

1 reference

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Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.

10 September 2017

1 reference

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Hypoxia-induced mitogenic factor has proangiogenic and proinflammatory effects in the lung via VEGF and VEGF receptor-2.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

von Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Impact of HIF-1alpha and HIF-2alpha on proliferation and migration of human pulmonary artery fibroblasts in hypoxia

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Measurement of pulmonary emphysema

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Regulation of tyrosine hydroxylase gene expression in the rat carotid body by hypoxia

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Adiponectin ameliorates hypoxia-induced pulmonary arterial remodeling

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Erythropoietin regulates hypoxic ventilation in mice by interacting with brainstem and carotid bodies

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Hypoxia-induced mitogenic factor has antiapoptotic action and is upregulated in the developing lung: coexpression with hypoxia-inducible factor-2alpha

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Altered pulmonary vascular reactivity in mice with excessive erythrocytosis.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Role of the C-terminal alpha-helical domain of the von Hippel-Lindau protein in its E3 ubiquitin ligase activity.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

FIZZ1/RELMα, a Novel Hypoxia-Induced Mitogenic Factor in Lung With Vasoconstrictive and Angiogenic Properties

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Mutations in the VHL gene in sporadic apparently congenital polycythemia

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Endemic polycythemia in Russia: mutation in the VHL gene.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Pulmonary Fibrosis and Chronic Lung Inflammation in ET-1 Transgenic Mice

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827942

Congenital polycythemia in Chuvashia

2 December 2018

1 reference

12 December 2020

Increased endothelin-1 and its localization during the development of bleomycin-induced pulmonary fibrosis in rats

1 reference

12 December 2020

The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid

1 reference

12 December 2020

Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells

1 reference

12 December 2020

Endothelin-1, vascular endothelial growth factor and systolic pulmonary artery pressure in patients with Chuvash polycythemia

1 reference

12 December 2020

Dissociation between alveolar transmigration of neutrophils and lung injury in hyperoxia

1 reference

12 December 2020

Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2

1 reference

12 December 2020

Tenascin expression and distribution in pleural inflammatory and fibrotic diseases

1 reference

12 December 2020

Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia

1 reference

12 December 2020

Chuvash-type congenital polycythemia in 4 families of Asian and Western European ancestry

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI36362

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20197624%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference