(Q39752665)

English

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia (English)

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

arterial hypertension

0 references

0 references

ventricular dysfunction

1 reference

based on heuristic

inferred from title

pulmonary hypertension

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Peter Carmeliet

7

object named as

Peter Carmeliet

1 reference

Europe PubMed Central

14 September 2017

PMC publication ID

0 references

author name string

Koen Brusselmans

1

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Veerle Compernolle

2

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Marc Tjwa

3

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Michael S Wiesener

4

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Patrick H Maxwell

5

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Désiré Collen

6

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

language of work or name

0 references

publication date

1 May 2003

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Journal of Clinical Investigation

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

111

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

10

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

1519-1527

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

Pulmonary hypertension in patients with chronic obstructive pulmonary disease: recent advances in pathophysiology and management

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

Pulmonary hypertension in COPD: old and new concepts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

Nitric oxide production in the hypoxic lung

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

Extrapulmonary effects of chronic obstructive pulmonary disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

Endothelin and pulmonary hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

Mechanisms of structural remodeling in chronic pulmonary hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

Nitric oxide synthases: Roles, tolls, and controls

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

22 September 2017

Hypoxia-inducible factor-2alpha (HIF-2alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

25 September 2017

Hypoxia-induced pulmonary vascular remodeling: a model for what human disease?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

25 September 2017

Cellular and molecular mechanisms of pulmonary vascular remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

25 September 2017

Vascular development and disorders: molecular analysis and pathogenic insights

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

17 June 2018

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

20 August 2018

Cell-based gene transfer of vascular endothelial growth factor attenuates monocrotaline-induced pulmonary hypertension.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

20 August 2018

Endogenously released endothelin-1 from human pulmonary artery smooth muscle promotes cellular proliferation: relevance to pathogenesis of pulmonary hypertension and vascular remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

20 August 2018

Prostacyclin receptor-dependent modulation of pulmonary vascular remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

20 August 2018

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

20 August 2018

Deficiency of urokinase-type plasminogen activator-mediated plasmin generation impairs vascular remodeling during hypoxia-induced pulmonary hypertension in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

20 August 2018

Suppression of tumor growth through disruption of hypoxia-inducible transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

20 August 2018

Gene transfer of endothelial nitric oxide synthase to the lung of the mouse in vivo. Effect on agonist-induced and flow-mediated vascular responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

20 August 2018

Continuous nitric oxide inhalation reduces pulmonary arterial structural changes, right ventricular hypertrophy, and growth retardation in the hypoxic newborn rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155039

20 August 2018

Immunohistochemical analysis of platelet-derived growth factor-B expression in myocardial tissues in hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12750401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic obstructive pulmonary disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12750401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aerosol gene transfer with inducible nitric oxide synthase reduces hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12750401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NADPH oxidase inhibitors iodonium diphenyl and cadmium sulphate inhibit hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteries

1 reference

https://pubmed.ncbi.nlm.nih.gov/12750401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of hypoxaemia on neuroendocrine function and catecholamine secretion in chronic obstructive pulmonary disease (COPD). Effects of long-term oxygen treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/12750401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12750401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased circulating plasma norepinephrine concentrations in noncardiac causes of pulmonary hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/12750401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The response of microvessels in rat lung explants to incubation with norepinephrine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12750401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha 1-adrenergic stimulation and beta 2-adrenergic inhibition of DNA synthesis in vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12750401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12750401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inositol trisphosphate is involved in norepinephrine- but not in hypoxia-induced pulmonary arterial contraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/12750401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological strategies for improving diastolic dysfunction in the setting of chronic pulmonary hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/12750401

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI15496

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q39752665&oldid=2203437665"