(Q39276818)

10 September 2017

title

FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells (English)

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10 September 2017

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B Dikshit

1

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10 September 2017

K Irshad

2

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10 September 2017

E Madan

3

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10 September 2017

N Aggarwal

4

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10 September 2017

C Sarkar

5

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10 September 2017

P S Chandra

6

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10 September 2017

D K Gupta

7

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10 September 2017

P Chattopadhyay

8

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10 September 2017

S Sinha

9

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10 September 2017

K Chosdol

10

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10 September 2017

language of work or name

English

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publication date

1 August 2013

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10 September 2017

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10 September 2017

volume

32

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10 September 2017

issue

33

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10 September 2017

page(s)

3798-3808

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https://scigraph.springernature.com/pub.10.1038/onc.2012.393

10 September 2017

exact match

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cites work

Inflammation and oncogenesis: a vicious connection

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Polymorphisms in COX-2 gene influence prostate cancer susceptibility in a northern Indian cohort.

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Inflammation and cancer: The oncogene-driven connection

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Glioblastoma cells: a heterogeneous and fatal tumor interacting with the parenchyma

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Sensing invasion: cell surface receptors driving spreading of glioblastoma.

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Growth factors, glia and gliomas

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Pro-inflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma

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ECM-mediated glioma cell invasion.

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Cancer and inflammation: implications for pharmacology and therapeutics

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Targeting inflammatory pathways for tumor radiosensitization.

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Towards understanding the role of cancer-associated inflammation in chemoresistance

21 January 2018

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Involvement of TNFα-induced TLR4-NF-κB and TLR4-HIF-1α feed-forward loops in the regulation of inflammatory responses in glioma.

21 January 2018

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Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE(2) activation

21 January 2018

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COX-2 regulates the proliferation of glioma stem like cells

21 January 2018

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Molecular therapeutic targets in inflammation: cyclooxygenase and NF-kappaB.

21 January 2018

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Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule

21 January 2018

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Delineation of a Fat tumor suppressor pathway

21 January 2018

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The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation

21 January 2018

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The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway.

21 January 2018

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The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.

21 January 2018

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Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway.

21 January 2018

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Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila

21 January 2018

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The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily

21 January 2018

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Immunohistological localisation of human FAT1 (hFAT) protein in 326 breast cancers. Does this adhesion molecule have a role in pathogenesis?

21 January 2018

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The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia

21 January 2018

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Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array

21 January 2018

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Phenotypic variability of a 4q34-->qter inherited deletion: MRKH syndrome in the daughter, cardiac defect and Fallopian tube cancer in the mother.

21 January 2018

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Frequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene 'FAT' in human astrocytic tumors

21 January 2018

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The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation

21 January 2018

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Programmed cell death protein 4 (pdcd4): a novel target for antineoplastic therapy?

21 January 2018

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Structure of the Tandem MA-3 Region of Pdcd4 Protein and Characterization of Its Interactions with eIF4A and eIF4G

21 January 2018

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Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.393

Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.393

MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.393

Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-kappaB or ODC transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Involvement of AP-1 in interleukin-1alpha-stimulated MMP-3 expression in human trabecular meshwork cells

21 January 2018

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Bucillamine mechanism inhibiting IL-1beta-induced VEGF production from fibroblast-like synoviocytes.

21 January 2018

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The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors.

21 January 2018

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The activator protein-1 transcription factor in respiratory epithelium carcinogenesis

21 January 2018

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Transcriptional regulation of cell invasion: AP-1 regulation of a multigenic invasion programme

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.393

Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.393

Akt phosphorylates and regulates Pdcd4 tumor suppressor protein

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.393

Programmed cell death 4 (PDCD4) enhances the sensitivity of gastric cancer cells to TRAIL-induced apoptosis by inhibiting the PI3K/Akt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation.

21 January 2018

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The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

21 January 2018

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Induction of c-jun protooncogene expression and transcription factor AP-1 activity by the polyoma virus middle-sized tumor antigen

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.393

c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Targeting cyclooxygenase-2 in human neoplasia: rationale and promise

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Role of IL-1 beta and COX2 in silica-induced IL-6 release and loss of pneumocytes in co-cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

PDCD4 gene silencing in gliomas is associated with 5'CpG island methylation and unfavourable prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

New insights into Fat cadherins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Differentially spliced isoforms of FAT1 are asymmetrically distributed within migrating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

The Fat1 cadherin integrates vascular smooth muscle cell growth and migration signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Programmed cell death 4 inhibits breast cancer cell invasion by increasing tissue inhibitor of metalloproteinases-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

An essential role of PDCD4 in progression and malignant proliferation of gastrointestinal stromal tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

PDCD4 inhibits the malignant phenotype of ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Targeting inflammation-induced transcription factor activation: an open frontier for glioma therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

IGF-1 induced HIF-1α-TLR9 cross talk regulates inflammatory responses in glioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas: correlation with angiogenesis and prognostic significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Inhibition of cyclooxygenase-2 enhances immunotherapy against experimental brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

The nonsteroidal anti-inflammatory drug celecoxib suppresses the growth and induces apoptosis of human glioblastoma cells via the NF-κB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Reduced risk of human lung cancer by selective cyclooxygenase 2 (COX-2) blockade: results of a case control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Cancer and inflammation: promise for biologic therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

An Essential Role of the Nuclear Factor of Activated T Cells in the Regulation of the Expression of the Cyclooxygenase-2 Gene in Human T Lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

From ancient medicine to modern medicine: ayurvedic concepts of health and their role in inflammation and cancer.

21 January 2018

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Therapy for glioma: Indian perspective.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Downregulation of tumor suppressor Pdcd4 promotes invasion and activates both beta-catenin/Tcf and AP-1-dependent transcription in colon carcinoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

AP-1 complexes containing cJun and JunB cause cellular transformation of Rat1a fibroblasts and share transcriptional targets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Inhibition of AP-1 transcription factor causes blockade of multiple signal transduction pathways and inhibits breast cancer growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Cyclooxygenase in the treatment of glioma: its complex role in signal transduction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Cancer chemoprevention by cyclooxygenase 2 (COX-2) blockade: results of case control studies.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Cyclooxygenase-2 (cox-2) and the inflammogenesis of cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.393

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7 January 2021

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Identifiers

DOI

10.1038/ONC.2012.393

1 reference

Dimensions Publication ID

10 September 2017

1040823784

0 references

Fatcat ID

release_pgind6it3nehdgmx3kqprdqova

0 references

1 reference