(Q39289613)

10 September 2017

title

Rearrangement of energetic and substrate utilization networks compensate for chronic myocardial creatine kinase deficiency (English)

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10 September 2017

3

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10 September 2017

Petras P Dzeja

1

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10 September 2017

Kirsten Hoyer

2

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10 September 2017

Song Zhang

4

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10 September 2017

Emirhan Nemutlu

5

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10 September 2017

Matthias Spindler

6

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10 September 2017

Joanne S Ingwall

7

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10 September 2017

language of work or name

English

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publication date

30 August 2011

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10 September 2017

number of pages

19

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inferred from page(s)

published in

Journal of Physiology

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10 September 2017

volume

589

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10 September 2017

issue

Pt 21

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10 September 2017

page(s)

5193-5211

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Coupling of cell energetics with membrane metabolic sensing. Integrative signaling through creatine kinase phosphotransfer disrupted by M-CK gene knock-out

10 September 2017

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Reduced myocardial creatine kinase flux in human myocardial infarction: an in vivo phosphorus magnetic resonance spectroscopy study

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Reduction of four-and-a-half LIM-protein 2 expression occurs in human left ventricular failure and leads to altered localization and reduced activity of metabolic enzymes

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Bioenergetic protection of failing atrial and ventricular myocardium by vasopeptidase inhibitor omapatrilat

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Failing atrial myocardium: energetic deficits accompany structural remodeling and electrical instability

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Glycolytic network restructuring integral to the energetics of embryonic stem cell cardiac differentiation

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Role of creatine kinase in cardiac excitation-contraction coupling: studies in creatine kinase-deficient mice

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Creatine kinase injection restores contractile function in creatine-kinase-deficient mouse skeletal muscle fibres

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Changes in glycolytic network and mitochondrial design in creatine kinase-deficient muscles

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Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing

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Defective metabolic signaling in adenylate kinase AK1 gene knock-out hearts compromises post-ischemic coronary reflow

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Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer.

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Failing energetics in failing hearts

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Phosphotransfer networks and cellular energetics

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Phosphotransfer dynamics in skeletal muscle from creatine kinase gene-deleted mice

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Adenylate kinase: kinetic behavior in intact cells indicates it is integral to multiple cellular processes

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Integrating metabolomics and phenomics with systems models of cardiac hypoxia

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Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis

21 January 2018

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Adenylate kinase isozyme 2 is essential for growth and development of Drosophila melanogaster.

21 January 2018

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AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer.

21 January 2018

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The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function.

21 January 2018

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Accumulation of 2-deoxy-D-glucose-6-phosphate as a measure of glucose uptake in the isolated perfused heart: a 31P NMR study

21 January 2018

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Whole-organ enzymology of the creatine kinase system in heart

21 January 2018

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Transgenesis and cardiac energetics: new insights into cardiac metabolism

21 January 2018

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Energy metabolism in heart failure and remodelling

21 January 2018

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On energy circuits in the failing myocardium

21 January 2018

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Adenylate kinase 1 gene deletion disrupts muscle energetic economy despite metabolic rearrangement

21 January 2018

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Impaired Intracellular Energetic Communication in Muscles from Creatine Kinase and Adenylate Kinase (M-CK/AK1) Double Knock-out Mice

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2011.212829

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

21 January 2018

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Tumor suppressors and cell metabolism: a recipe for cancer growth

21 January 2018

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Contraction-mediated glycogenolysis in mouse skeletal muscle lacking creatine kinase: the role of phosphorylase b activation

21 January 2018

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Metabolic therapy at the crossroad: how to optimize myocardial substrate utilization?

21 January 2018

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Local ATP generation by brain-type creatine kinase (CK-B) facilitates cell motility

21 January 2018

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Interaction of NDPK-D with cardiolipin-containing membranes: Structural basis and implications for mitochondrial physiology.

21 January 2018

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Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness

21 January 2018

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Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2

21 January 2018

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Serum 1H-nuclear magnetic spectroscopy followed by principal component analysis and hierarchical cluster analysis to demonstrate effects of statins on hyperlipidemic patients

21 January 2018

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Reverse cardiac remodeling enabled by mechanical unloading of the left ventricle

21 January 2018

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Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells

21 January 2018

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Multimodal functional cardiac MRI in creatine kinase-deficient mice reveals subtle abnormalities in myocardial perfusion and mechanics

21 January 2018

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In situ measurements of creatine kinase flux by NMR. The lessons from bioengineered mice

21 January 2018

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21 January 2018

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Assessment of metabolic phenotypes in patients with non-ischemic dilated cardiomyopathy undergoing cardiac resynchronization therapy

21 January 2018

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Suppression of adenylate kinase catalyzed phosphotransfer precedes and is associated with glucose-induced insulin secretion in intact HIT-T15 cells

21 January 2018

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Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2.

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2011.212829

Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2011.212829

Adenylate kinase AK1 knockout heart: energetics and functional performance under ischemia-reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2011.212829

Mapping hypoxia-induced bioenergetic rearrangements and metabolic signaling by 18O-assisted 31P NMR and 1H NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2011.212829

Cellular energetics in the preconditioned state: protective role for phosphotransfer reactions captured by 18O-assisted 31P NMR.

21 January 2018

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https://api.crossref.org/works/10.1113%2FJPHYSIOL.2011.212829

Multivariate analysis of fMRI data by oriented partial least squares

21 January 2018

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32P labelling of the nucleotides in α-position in the rabbit heart

21 January 2018

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Cardiac system bioenergetics: metabolic basis of the Frank-Starling law.

21 January 2018

1 reference

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Metabolic compartmentation and substrate channelling in muscle cells. Role of coupled creatine kinases in in vivo regulation of cellular respiration--a synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2011.212829

Kinetic, thermodynamic, and developmental consequences of deleting creatine kinase isoenzymes from the heart. Reaction kinetics of the creatine kinase isoenzymes in the intact heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2011.212829

The fall in creatine levels and creatine kinase isozyme changes in the failing heart are reversible: complex post-transcriptional regulation of the components of the CK system

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2011.212829

Creatine kinase-deficient hearts exhibit increased susceptibility to ischemia-reperfusion injury and impaired calcium homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2011.212829

Mitochondrial creatine kinase is critically necessary for normal myocardial high-energy phosphate metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2011.212829

Substrate metabolism as a determinant for postischemic functional recovery of the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2011.212829

Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2011.212829

Transcriptional regulation of energy substrate metabolism in normal and hypertrophied heart

21 January 2018

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A metabolomic and multivariate statistical process to assess the effects of genotoxins in Saccharomyces cerevisiae

21 January 2018

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Bioenergetics of the failing heart

21 January 2018

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Structural and functional adaptations of striated muscles to CK deficiency.

21 January 2018

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Muscle creatine kinase-deficient mice. I. Alterations in myofibrillar function.

21 January 2018

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Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis

21 January 2018

1 reference

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Bidirectional reaction steps in metabolic networks: I. Modeling and simulation of carbon isotope labeling experiments.

21 January 2018

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Creatine and creatine kinase in health and disease--a bright future ahead?

21 January 2018

2 references

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2011.212829

21 January 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225674

ATP production rate via creatine kinase or ATP synthase in vivo: a novel superfast magnetization saturation transfer method

4 November 2018

1 reference

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Regulation of sodium-calcium exchanger activity by creatine kinase under energy-compromised conditions.

21 January 2018

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High-energy phosphate metabolism and creatine kinase in failing hearts: a new porcine model

21 January 2018

1 reference

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ON THE CALCULATION OF "TURNOVER TIME" AND "TURNOVER RATE" FROM EXPERIMENTS INVOLVING THE USE OF LABELING AGENTS.

21 January 2018

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Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

21 January 2018

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Energetics of the failing heart: new insights using genetic modification in the mouse.

4 November 2018

1 reference

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Measurement of Microbial Nucleic Acid Synthesis and Specific Growth Rate by PO(4) and [H]Adenine: Field Comparison

4 November 2018

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Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity

4 November 2018

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Evaluation of carbon flux and substrate selection through alternate pathways involving the citric acid cycle of the heart by 13C NMR spectroscopy.

4 November 2018

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Evidence for compartmentalized adenylate kinase catalysis serving a high energy phosphoryl transfer function in rat skeletal muscle

4 November 2018

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Analysis of tricarboxylic acid cycle of the heart using 13C isotope isomers

4 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225674

Ischemic contracture begins when anaerobic glycolysis stops: a 31P-NMR study of isolated rat hearts

4 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225674

Kinetics and compartmentation of energy metabolism in intact skeletal muscle determined from 18O labeling of metabolite phosphoryls

4 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3225674

Reporting ethical matters in the Journal of Physiology: standards and advice

4 November 2018

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Adenylate kinase-catalyzed phosphotransfer in the myocardium : increased contribution in heart failure

21 January 2018

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12 December 2020

Long-Term Effects of Increased Glucose Entry on Mouse Hearts During Normal Aging and Ischemic Stress

1 reference

12 December 2020

Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy

1 reference

12 December 2020

The creatine kinase system in normal and diseased human myocardium

1 reference

12 December 2020

Relation between work and phosphate metabolite in the in vivo paced mammalian heart

1 reference

12 December 2020

Altered Ca2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies

1 reference

12 December 2020

Metabolomic Profiling of Cardiac Substrate Utilization

1 reference

12 December 2020

Suppression of creatine kinase-catalyzed phosphotransfer results in increased phosphoryl transfer by adenylate kinase in intact skeletal muscle

1 reference

12 December 2020

Compromised energetics in the adenylate kinase AK1 gene knockout heart under metabolic stress

1 reference

12 December 2020

Adenylate kinase-catalyzed phosphoryl transfer couples ATP utilization with its generation by glycolysis in intact muscle

1 reference

12 December 2020

Impaired cardiac energetics in mice lacking muscle-specific isoenzymes of creatine kinase

1 reference

12 December 2020

10.1113/JPHYSIOL.2011.212829

Identifiers

DOI

1 reference

10 September 2017

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