(Q39291844)

English

Antifibrotic activity of sorafenib in experimental hepatic fibrosis: refinement of inhibitory targets, dosing, and window of efficacy in vivo

scientific article published on 24 August 2012

In more languages

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Antifibrotic activity of sorafenib in experimental hepatic fibrosis: refinement of inhibitory targets, dosing, and window of efficacy in vivo (English)

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

author name string

Feng Hong

1

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Hsini Chou

2

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Maria Isabel Fiel

3

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Scott L Friedman

4

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

publication date

24 August 2012

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Digestive Diseases and Sciences

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

58

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

1

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

257-264

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

https://scigraph.springernature.com/pub.10.1007/s10620-012-2314-1

0 references

Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

10 September 2017

Mechanisms of hepatic fibrogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

10 September 2017

Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

10 September 2017

Sorafenib in advanced hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

10 September 2017

Myofibroblast - like cells and liver fibrogenesis: Emerging concepts in a rapidly moving scenario.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

10 September 2017

Pro-fibrogenic potential of PDGF-D in liver fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

10 September 2017

Sorafenib in advanced clear-cell renal-cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

10 September 2017

TGF-beta and epithelial-to-mesenchymal transitions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

10 September 2017

Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

10 September 2017

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

10 September 2017

Cytokine receptors and signaling in hepatic stellate cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

10 September 2017

Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

10 September 2017

Transforming growth factor beta1 induces the expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C/EBPbeta-dependent mechanism in rat hepatic stellate cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

10 September 2017

Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

10 September 2017

Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

14 September 2017

Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

14 September 2017

New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

21 August 2018

Tissue inhibitor of metalloproteinases-1 attenuates spontaneous liver fibrosis resolution in the transgenic mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

21 August 2018

Reproducible production of thioacetamide-induced macronodular cirrhosis in the rat with no mortality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3543488

21 August 2018

Physiology and organ-related pathology of the elderly: stomach ulcers

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Acid-related disorders in the elderly

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Recent trends in admissions and mortality due to peptic ulcer in England: increasing frequency of haemorrhage among older subjects

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Bleeding peptic ulcer in the elderly: risk factors and prevention strategies

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Aging and upper gastrointestinal disorders

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Inappropriate prevention of NSAID-induced gastrointestinal events among long-term users in the elderly

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Molecular inflammation as an underlying mechanism of the aging process and age-related diseases

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Aging up-regulates expression of inflammatory mediators in mouse adipose tissue

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

The molecular inflammatory process in aging

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Molecular inflammation: underpinnings of aging and age-related diseases

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

The NF-kappa B and I kappa B proteins: new discoveries and insights

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Cloning, sequence comparison and in vivo expression of the gene encoding rat P-selectin

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Reemergence of macrolide resistance in pharyngeal isolates of group a streptococci in southwestern Pennsylvania

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Drug-related damage of the ageing gastrointestinal tract

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Acid peptic disease in the elderly

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Aging is characterized by a profound reduction in anti-inflammatory lipoxin A4 levels.

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Anti-inflammatory circuitry: lipoxin, aspirin-triggered lipoxins and their receptor ALX

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Lipoxin and aspirin-triggered lipoxins.

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Roles of oxidative stress in stomach disorders.

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Significance of protein tyrosine kinase/protein tyrosine phosphatase balance in the regulation of NF-kappaB signaling in the inflammatory process and aging.

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

The effect of age on cyclooxygenase-2 gene expression: NF-kappaB activation and IkappaBalpha degradation

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Inflammation and immune regulation by 12/15-lipoxygenases

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Oxidative stress and vascular aging

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention

1 reference

https://api.crossref.org/works/10.1007%2FS10620-012-2314-1

21 January 2018

Thioacetamide-induced cirrhosis-like liver lesions in rats--usefulness and reliability of this animal model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22918681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolated hepatic lipocytes and kupffer cells from normal human liver: Morphological and functional characteristics in primary culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/22918681

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10620-012-2314-1

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

reason for deprecated rank

incorrect identifier value

0 references

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