(Q39295075)

10 September 2017

title

CD4⁺ T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer (English)

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10 September 2017

6

Luigi Naldini

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Laura Passerini

object named as

Laura Passerini

1

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Georgia Fousteri

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Georgia Fousteri

4

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Maria Grazia Roncarolo

object named as

Maria Grazia Roncarolo

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author name string

Eva Rossi Mel

2

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10 September 2017

Claudia Sartirana

3

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10 September 2017

Attilio Bondanza

5

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10 September 2017

Rosa Bacchetta

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10 September 2017

language of work or name

English

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publication date

1 December 2013

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Science Translational Medicine

10 September 2017

published in

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10 September 2017

volume

5

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10 September 2017

issue

215

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10 September 2017

page(s)

215ra174

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Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency

10 September 2017

cites work

1 reference

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Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

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The immunogenetics of immune dysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome

21 January 2018

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Demethylation analysis of the FOXP3 locus shows quantitative defects of regulatory T cells in IPEX-like syndrome.

21 January 2018

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Defective regulatory and effector T cell functions in patients with FOXP3 mutations.

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Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy

21 January 2018

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Immune dysregulation, polyendocrinopathy, enteropathy, x-linked syndrome: a paradigm of immunodeficiency with autoimmunity

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IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity.

21 January 2018

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Rescue of the autoimmune scurfy mouse by partial bone marrow transplantation or by injection with T-enriched splenocytes

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Gene therapy for immunodeficiency due to adenosine deaminase deficiency.

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Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

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Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

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Regulatory T cells in stem cell transplantation: strategies and first clinical experiences.

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Immune intervention with T regulatory cells: past lessons and future perspectives for type 1 diabetes.

21 January 2018

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Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3.

21 January 2018

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HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells

21 January 2018

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ChIP-on-chip analysis identifies IL-22 as direct target gene of ectopically expressed FOXP3 transcription factor in human T cells

21 January 2018

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Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes

21 January 2018

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Enforced IL-10 expression confers type 1 regulatory T cell (Tr1) phenotype and function to human CD4(+) T cells.

21 January 2018

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Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells

21 January 2018

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A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells

21 January 2018

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Plasticity of CD4(+) FoxP3(+) T cells

21 January 2018

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Identification of IL-17-producing FOXP3+ regulatory T cells in humans.

21 January 2018

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Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells

21 January 2018

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21 January 2018

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21 January 2018

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FOXP3 controls regulatory T cell function through cooperation with NFAT

21 January 2018

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Human T regulatory cells can use the perforin pathway to cause autologous target cell death

21 January 2018

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Site-specific accumulation of recently activated CD4+ Foxp3+ regulatory T cells following adoptive transfer.

21 January 2018

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Selective engraftment of donor CD4+25high FOXP3-positive T cells in IPEX syndrome after nonmyeloablative hematopoietic stem cell transplantation

21 January 2018

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Therapeutic in vivo selection of thymic-derived natural T regulatory cells following non-myeloablative hematopoietic stem cell transplant for IPEX.

21 January 2018

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Wild-type FOXP3 is selectively active in CD4+CD25(hi) regulatory T cells of healthy female carriers of different FOXP3 mutations

21 January 2018

1 reference

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Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters.

21 January 2018

1 reference

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Regulated and multiple miRNA and siRNA delivery into primary cells by a lentiviral platform

21 January 2018

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Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level

21 January 2018

1 reference

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10.1126/SCITRANSLMED.3007320

21 January 2018

Identifiers

DOI

1 reference

release_ew4ik3aeofcpxbp4wscey4asti

10 September 2017

Fatcat ID

0 references

1 reference