(Q39312939)

10 September 2017

title

The dynamics of the CHO host cell protein profile during clarification and protein A capture in a platform antibody purification process (English)

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10 September 2017

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Catherine E M Hogwood

1

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10 September 2017

Andrew S Tait

2

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10 September 2017

Nadejda Koloteva-Levine

3

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10 September 2017

Daniel G Bracewell

4

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10 September 2017

C Mark Smales

5

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10 September 2017

publication date

6 August 2012

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Biotechnology and Bioengineering

10 September 2017

published in

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10 September 2017

volume

110

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10 September 2017

issue

1

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10 September 2017

page(s)

240-251

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On the statistical analysis of the GS-NS0 cell proteome: imputation, clustering and variability testing.

10 September 2017

cites work

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Proteomic analysis of enriched microsomal fractions from GS-NS0 murine myeloma cells with varying secreted recombinant monoclonal antibody productivities

21 January 2018

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Ultra scale-down to define and improve the relationship between flocculation and disc-stack centrifugation

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Performance prediction of industrial centrifuges using scale-down models.

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Advances in the production and downstream processing of antibodies

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2-D DIGE to expedite downstream process development for human monoclonal antibody purification

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Two-dimensional difference fluorescence gel electrophoresis to verify the scale-up of a non-affinity-based downstream process for isolation of a therapeutic recombinant antibody.

21 January 2018

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A method for three-dimensional protein characterization and its application to a complex plant (corn) extract.

21 January 2018

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Separation science is the key to successful biopharmaceuticals

21 January 2018

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Shear stress analysis of mammalian cell suspensions for prediction of industrial centrifugation and its verification

21 January 2018

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Profiling of host cell proteins by two-dimensional difference gel electrophoresis (2D-DIGE): Implications for downstream process development.

21 January 2018

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Transient expression of human TorsinA enhances secretion of two functionally distinct proteins in cultured Chinese hamster ovary (CHO) cells

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Proteomic studies support the use of multi-product immunoassays to monitor host cell protein impurities

21 January 2018

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BiP and immunoglobulin light chain cooperate to control the folding of heavy chain and ensure the fidelity of immunoglobulin assembly

21 January 2018

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Use of proteomics for design of a tailored host cell for highly efficient protein purification.

21 January 2018

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Future of antibody purification

21 January 2018

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Identification of the limitations on recombinant gene expression in CHO cell lines with varying luciferase production rates

21 January 2018

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Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype

21 January 2018

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Antibody capture by mixed-mode chromatography: a comprehensive study from determination of optimal purification conditions to identification of contaminating host cell proteins.

21 January 2018

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Biochemical insights into the mechanisms central to the response of mammalian cells to cold stress and subsequent rewarming

21 January 2018

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Host cell protein clearance during protein A chromatography: development of an improved column wash step.

21 January 2018

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Recent advances in large-scale production of monoclonal antibodies and related proteins

21 January 2018

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Host cell protein dynamics in the supernatant of a mAb producing CHO cell line

21 January 2018

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Host cell proteins in biologics development: Identification, quantitation and risk assessment

21 January 2018

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Modeling industrial centrifugation of mammalian cell culture using a capillary based scale-down system.

21 January 2018

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High-throughput screening of packed-bed chromatography coupled with SELDI-TOF MS analysis: monoclonal antibodies versus host cell protein

21 January 2018

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Production of recombinant protein therapeutics in cultivated mammalian cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIT.24607

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10 September 2017

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