(Q39319459)

11 September 2017

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title

The Mechanisms of Action of Curcumin in Alzheimer's Disease (English)

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11 September 2017

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Mengxi Tang

1

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PubMed ID

28527218

11 September 2017

Changiz Taghibiglou

series ordinal

2

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11 September 2017

17 May 2017

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Journal of Alzheimer's Disease

11 September 2017

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11 September 2017

58

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11 September 2017

4

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11 September 2017

1003-1016

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https://api.crossref.org/works/10.3233%2FJAD-170188

11 September 2017

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The worldwide costs of dementia 2015 and comparisons with 2010

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Natural products as promising drug candidates for the treatment of Alzheimer's disease: molecular mechanism aspect

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Linking lipids to Alzheimer's disease: cholesterol and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

A review on Alzheimer's disease pathophysiology and its management: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer's and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Membrane-mediated neuroprotection by curcumin from amyloid-β-peptide-induced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Targeting Beta amyloid: a clinical review of immunotherapeutic approaches in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Revisiting the cholinergic hypothesis in the development of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Acetylcholinesterase inhibitors: pharmacology and toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Role of Glutamate and NMDA Receptors in Alzheimer's Disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin: the Indian solid gold

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Discovery of curcumin, a component of golden spice, and its miraculous biological activities

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Incidence of Alzheimer's disease in a rural community in India: the Indo-US study

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin Ameliorates Memory Decline via Inhibiting BACE1 Expression and β-Amyloid Pathology in 5×FAD Transgenic Mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin mediates presenilin-1 activity to reduce β-amyloid production in a model of Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Downstream modulation of extrinsic apoptotic pathway in streptozotocin-induced Alzheimer's dementia in rats: Erythropoietin versus curcumin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Structure-activity relationships of amyloid beta-aggregation inhibitors based on curcumin: influence of linker length and flexibility.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Protection of curcumin against amyloid-β-induced cell damage and death involves the prevention from NMDA receptor-mediated intracellular Ca2+ elevation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin Attenuates Amyloid-β Aggregate Toxicity and Modulates Amyloid-β Aggregation Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin attenuates amyloid-β-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN/Akt/GSK-3β signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin improves tau-induced neuronal dysfunction of nematodes

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Serum zinc levels and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Copper dysfunction in Alzheimer's disease: from meta-analysis of biochemical studies to new insight into genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Copper Ion Binding Site in β-Amyloid Peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Oxidative stress and antioxidant defense

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Copper-induced structural conversion templates prion protein oligomerization and neurotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Complexation between Cu(II) and curcumin in the presence of two different segments of amyloid β.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Dual effects of curcumin on neuronal oxidative stress in the presence of Cu(II).

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Serum cholesterol changes after midlife and late-life cognition: twenty-one-year follow-up study.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Comparative lipidomic analysis of mouse and human brain with Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Imbalanced cholesterol metabolism in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Cholesterol: its regulation and role in central nervous system disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Early Statin Use and the Progression of Alzheimer Disease: A Total Population-Based Case-Control Study

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Role of NMDA receptor-dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin rescues high fat diet-induced obesity and insulin sensitivity in mice through regulating SREBP pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin inhibits cellular cholesterol accumulation by regulating SREBP-1/caveolin-1 signaling pathway in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin induces changes in expression of genes involved in cholesterol homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Microglia function in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin inhibits Aβ-induced microglial inflammatory responses in vitro: Involvement of ERK1/2 and p38 signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

PI3k/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer's Disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin improves episodic memory in cadmium induced memory impairment through inhibition of acetylcholinesterase and adenosine deaminase activities in a rat model.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin attenuates memory deficits and the impairment of cholinergic and purinergic signaling in rats chronically exposed to cadmium.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin Protects against Monosodium Glutamate Neurotoxicity and Decreasing NMDA2B and mGluR5 Expression in Rat Hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Protective effect of curcumin against chronic alcohol-induced cognitive deficits and neuroinflammation in the adult rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Brain insulin resistance in Alzheimer's disease and its potential treatment with GLP-1 analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin ameliorates insulin signalling pathway in brain of Alzheimer's disease transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin ameliorates impaired insulin/IGF signalling and memory deficit in a streptozotocin-treated rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Antioxidant and radical scavenging properties of curcumin

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Natural Compounds Modulating Mitochondrial Functions

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin inhibits apoptosis by regulating intracellular calcium release, reactive oxygen species and mitochondrial depolarization levels in SH-SY5Y neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Reversal of Beta-Amyloid-Induced Neurotoxicity in PC12 Cells by Curcumin, the Important Role of ROS-Mediated Signaling and ERK Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Protective effects of a natural product, curcumin, against amyloid β induced mitochondrial and synaptic toxicities in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Neuroprotective properties of curcumin in Alzheimer's disease--merits and limitations.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Dietary factors affecting polyphenol bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Synthetic Curcumin Analogs as Inhibitors of β -Amyloid Peptide Aggregation: Potential Therapeutic and Diagnostic Agents for Alzheimer's Disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Curcumin as potential therapeutic natural product: a nanobiotechnological perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Bioavailability of curcumin: problems and promises

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

High bioavailability curcumin: an anti-inflammatory and neurosupportive bioactive nutrient for neurodegenerative diseases characterized by chronic neuroinflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

The Essential Medicinal Chemistry of Curcumin

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170188

Biological activities of Curcuma longa L.

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1590/S0074-02762001000500026

Identifiers

DOI

10.3233/JAD-170188

1 reference

release_zbpvkc5nb5agjd3lcfr2xropti

11 September 2017

0 references

PubMed ID

28527218

1 reference

PubMed ID

28527218