(Q39335734)

11 September 2017

title

p62/sequestosome 1 binds to TDP-43 in brains with frontotemporal lobar degeneration with TDP-43 inclusions (English)

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frontotemporal lobar degeneration

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main subject

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Kunikazu Tanji

1

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Hai-Xin Zhang

2

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Fumiaki Mori

3

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Akiyoshi Kakita

4

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Hitoshi Takahashi

5

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Koichi Wakabayashi

6

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publication date

5 June 2012

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Journal of Neuroscience Research

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published in

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11 September 2017

volume

90

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issue

10

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page(s)

2034-2042

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TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

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cites work

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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

21 January 2018

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Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism

21 January 2018

1 reference

Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates

21 January 2018

1 reference

Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism.

21 January 2018

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White matter lesions in the brain with frontotemporal lobar degeneration with motor neuron disease: TDP-43-immunopositive inclusions co-localize with p62, but not ubiquitin.

21 January 2018

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Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

21 January 2018

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p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

21 January 2018

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Selective autophagy mediated by autophagic adapter proteins

21 January 2018

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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

21 January 2018

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Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

21 January 2018

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Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis

21 January 2018

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Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

21 January 2018

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Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

21 January 2018

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A harmonized classification system for FTLD-TDP pathology

21 January 2018

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Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

21 January 2018

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

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Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.

21 January 2018

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Course and causes of suspected dementia in young adults: a longitudinal study

21 January 2018

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Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies.

21 January 2018

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Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation

21 January 2018

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TDP-43 is a developmentally regulated protein essential for early embryonic development

21 January 2018

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Protein synthesis upon acute nutrient restriction relies on proteasome function

21 January 2018

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TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

21 January 2018

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Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation

21 January 2018

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Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice

21 January 2018

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Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2).

21 January 2018

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Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JNR.23081

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11 September 2017

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