(Q39340075)

English

Histone methyltransferase NSD2/MMSET mediates constitutive NF-κB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop

scientific article published on 29 May 2012

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scholarly article

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Europe PubMed Central

PMC publication ID

11 September 2017

Histone methyltransferase NSD2/MMSET mediates constitutive NF-κB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop (English)

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

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author name string

Ping Yang

1

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Europe PubMed Central

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11 September 2017

Linlang Guo

2

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11 September 2017

Zhijian J Duan

3

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11 September 2017

Clifford G Tepper

4

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11 September 2017

Ling Xue

5

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11 September 2017

Xinbin Chen

6

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11 September 2017

Hsing-Jien Kung

7

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11 September 2017

Allen C Gao

8

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11 September 2017

June X Zou

9

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11 September 2017

Hong-Wu Chen

10

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11 September 2017

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publication date

29 May 2012

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11 September 2017

Molecular and Cellular Biology

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11 September 2017

32

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11 September 2017

15

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11 September 2017

3121-3131

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Europe PubMed Central

PMC publication ID

11 September 2017

The diverse and complex roles of NF-κB subunits in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming

1 reference

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11 September 2017

CBP mediates NF-κB-dependent histone acetylation and estrogen receptor recruitment to an estrogen response element in the BIRC3 promoter

1 reference

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11 September 2017

Hierarchies of NF-κB target-gene regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

Histone methylation by PRC2 is inhibited by active chromatin marks

1 reference

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11 September 2017

Minireview: Alternative activation pathways for the androgen receptor in prostate cancer

1 reference

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11 September 2017

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR.

1 reference

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11 September 2017

Transducin β-like protein 1 recruits nuclear factor κB to the target gene promoter for transcriptional activation.

1 reference

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11 September 2017

NF-κB addiction and its role in cancer: 'one size does not fit all'.

1 reference

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11 September 2017

Activation of NF-{kappa}B by TMPRSS2/ERG Fusion Isoforms through Toll-Like Receptor-4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

ANCCA/ATAD2 Overexpression Identifies Breast Cancer Patients with Poor Prognosis, Acting to Drive Proliferation and Survival of Triple-Negative Cells through Control of B-Myb and EZH2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

1 reference

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11 September 2017

Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

NF-kappaB regulates androgen receptor expression and prostate cancer growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent kinase 9/cyclin T1 complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

NF-kappaB RelA phosphorylation regulates RelA acetylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex

1 reference

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11 September 2017

The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1

1 reference

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11 September 2017

NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

Transcriptional activation by NF-kappaB requires multiple coactivators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

11 September 2017

Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

14 September 2017

A feed-forward circuit controlling inducible NF-κB target gene activation by promoter histone demethylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

14 September 2017

Aberrant activation of the androgen receptor by NF-kappaB2/p52 in prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

14 September 2017

Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

14 September 2017

The homeodomain protein HOXB13 regulates the cellular response to androgens

1 reference

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14 September 2017

Hyperactivated NF-{kappa}B and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells

1 reference

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14 September 2017

RelB enhances prostate cancer growth: implications for the role of the nuclear factor-kappaB alternative pathway in tumorigenicity

1 reference

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14 September 2017

The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription

1 reference

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14 September 2017

Interleukin-6 stimulation of growth of prostate cancer in vitro and in vivo through activation of the androgen receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

14 September 2017

Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation

1 reference

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14 September 2017

Interleukin-8 signaling promotes androgen-independent proliferation of prostate cancer cells via induction of androgen receptor expression and activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

14 September 2017

The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

14 September 2017

ACTR/AIB1/SRC-3 and androgen receptor control prostate cancer cell proliferation and tumor growth through direct control of cell cycle genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

14 September 2017

Effects of IKK inhibitor PS1145 on NF-kappaB function, proliferation, apoptosis and invasion activity in prostate carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

14 September 2017

SRC-3 is required for prostate cancer cell proliferation and survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

14 September 2017

Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression

1 reference

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14 September 2017

Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways

1 reference

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14 September 2017

Interleukin-8 confers androgen-independent growth and migration of LNCaP: differential effects of tyrosine kinases Src and FAK.

1 reference

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14 September 2017

Bcl-6 and NF-kappaB cistromes mediate opposing regulation of the innate immune response.

1 reference

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25 September 2017

The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors

1 reference

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21 August 2018

The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

21 August 2018

ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors.

1 reference

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21 August 2018

Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

21 August 2018

Integrative microarray analysis of pathways dysregulated in metastatic prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

21 August 2018

Expression of nuclear factor-kappa B and I kappa B alpha proteins in prostatic adenocarcinomas: correlation of nuclear factor-kappa B immunoreactivity with disease recurrence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

21 August 2018

Nuclear Localization of Nuclear Factor- B p65 in Primary Prostate Tumors Is Highly Predictive of Pelvic Lymph Node Metastases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

2 December 2018

Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3434505

2 December 2018

Identifiers

10.1128/MCB.00204-12

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 September 2017

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