(Q40371781)

19 September 2017

title

Effects of IKK inhibitor PS1145 on NF-kappaB function, proliferation, apoptosis and invasion activity in prostate carcinoma cells (English)

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19 September 2017

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Yemelyanov A

1

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19 September 2017

Gasparian A

2

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19 September 2017

Lindholm P

3

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19 September 2017

Dang L

4

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19 September 2017

Pierce JW

5

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19 September 2017

Kisseljov F

6

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19 September 2017

Karseladze A

7

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19 September 2017

Budunova I

8

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19 September 2017

language of work or name

English

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publication date

1 January 2006

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19 September 2017

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19 September 2017

volume

25

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19 September 2017

issue

3

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19 September 2017

page(s)

387-398

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209066

19 September 2017

exact match

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Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors

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BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice

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Novel IKK inhibitors: beta-carbolines

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Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer

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Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1

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NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer

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Expression and function of androgen receptor coactivators in prostate cancer

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Aven and Bcl-xL enhance protection against apoptosis for mammalian cells exposed to various culture conditions

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Missing pieces in the NF-kappaB puzzle

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Interleukin-6 is an autocrine growth factor in human prostate cancer.

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Identification and characterization of nuclear factor kappaB binding sites in the murine bcl-x promoter.

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The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer

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Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells

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NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.

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Bcl-2 suppresses apoptosis resulting from disruption of the NF-kappa B survival pathway

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NF-kappa B as a therapeutic target in multiple myeloma

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Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.

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Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis

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Characterization of the recombinant IKK1/IKK2 heterodimer. Mechanisms regulating kinase activity

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Three NF-kappa B sites in the I kappa B-alpha promoter are required for induction of gene expression by TNF alpha

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Mitogen activated protein kinases as targets for development of novel anti-inflammatory drugs

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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NF-kappaB in cancer: from innocent bystander to major culprit

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NF-kappaB at the crossroads of life and death

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A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts

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To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosis

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Prostate stem cell antigen is overexpressed in prostate cancer metastases

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The emerging role of the PI3-K-Akt pathway in prostate cancer progression

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The role of constitutive NF-kappaB activity in PC-3 human prostate cancer cell invasive behavior

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Bacterial lipopolysaccharide, TNF-alpha, and calcium ionophore under serum-free conditions promote rapid dendritic cell-like differentiation in CD14+ monocytes through distinct pathways that activate NK-kappa B

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NF-kappaB as a therapeutic target in cancer

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Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen

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The flip side of FLIP

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Bcl-2 proteins: master switches at the intersection of death signaling and the survival control by Raf kinases

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Aberrant rel/nfkb genes and activity in human cancer

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Expression of nuclear factor-kappa B and I kappa B alpha proteins in prostatic adenocarcinomas: correlation of nuclear factor-kappa B immunoreactivity with disease recurrence

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Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis

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7 January 2021

Suppression of constitutive and tumor necrosis factor alpha-induced nuclear factor (NF)-kappaB activation and induction of apoptosis by apigenin in human prostate carcinoma PC-3 cells: correlation with down-regulation of NF-kappaB-responsive genes

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7 January 2021

Nuclear factor-kappaB/p65 (Rel A) is constitutively activated in human prostate adenocarcinoma and correlates with disease progression

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7 January 2021

Mechanisms of constitutive NF-kappaB activation in human prostate cancer cells

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Nuclear factor-kappaB is constitutively activated in prostate cancer in vitro and is overexpressed in prostatic intraepithelial neoplasia and adenocarcinoma of the prostate.

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7 January 2021

Members of the nuclear factor kappa B family transactivate the murine c-myb gene

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Combination of tumor necrosis factor-alpha with sulindac in human carcinoma cells in vivo

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A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209066

1 reference

Dimensions Publication ID

19 September 2017

1028162363

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1 reference